(R)-3-Aminopiperidine dihydrochloride

Base Information

• Chemical Name: (R)-3-Aminopiperidine dihydrochloride
• CAS No.: 334618-23-4
• Molecular Formula: C₅H₁₂N₂*ClH
• Molecular Weight: 136.625
• Hs Code.: 29339900
• European Community (EC) Number: 608-870-9
• DSSTox Substance ID: DTXSID40583408
• Mol file: 334618-23-4.mol

Synonyms:334618-23-4;(R)-3-AMINOPIPERIDINE DIHYDROCHLORIDE;(r)-piperidin-3-amine dihydrochloride;(R)-(-)-3-Aminopiperidine dihydrochloride;(R)-3-Piperidinamine dihydrochloride;(R)-3-Aminopiperidine 2hcl;(3R)-piperidin-3-amine dihydrochloride;(3R)-piperidin-3-amine;dihydrochloride;MFCD06799458;R-3-Aminopiperidine Dihydrochloride;3-PIPERIDINAMINE, DIHYDROCHLORIDE, (3R)-;SCHEMBL306090;DTXSID40583408;3-amino-piperidine-dihydrochloride;GGPNYXIOFZLNKW-ZJIMSODOSA-N;CS-B0670;(r)-piperidin-3-aminedihydrochloride;3-(R)-aminopiperidine dihydrochloride;AKOS015845481;(r)-piperidine-3-amine dihydrochloride;AC-6185;DS-0861;PS-8651;(R)-3-amino-piperidine, dihydrochloride;A5960;AM20090508;EN300-216851;(R)-(-)-3-Aminopiperidine dihydrochloride, 97%;(R)-(-)-3-PIPERIDINAMINE DIHYDROCHLORIDE;(3R)-Piperidin-3-amine--hydrogen chloride (1/2);J-650012;J-650226;W-202369;(R)-(-)-3-Aminopiperidine dihydrochloride, >=98.0% (GC)

Chemical Property of (R)-3-Aminopiperidine dihydrochloride

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 190-195 °C
• Boiling Point: 241.9 °C at 760 mmHg
• Flash Point: 100.1 °C
• PSA: 38.05000
• LogP: 2.33020
• Storage Temp.: Room temperature.
• Sensitive.: Hygroscopic
• Solubility.: Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.0534038
• Heavy Atom Count: 9
• Complexity: 54

Purity/Quality:

≥98.0% ^*data from raw suppliers

(R)-(-)-3-Aminopiperidine Dihydrochloride >97.0%(N)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-39-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CNC1)N.Cl.Cl
• Isomeric SMILES: C1C[C@H](CNC1)N.Cl.Cl
• Chemical structure: (R)-3-Aminopiperidine dihydrochloride is a chiral compound with a piperidine ring structure and two hydrochloride ions.
• Uses: Used as a reactant for the preparation of dipeptidyl peptidase IV inhibitors derived from Alogliptin. Key chiral intermediate in the synthesis of drugs for the treatment of type II diabetes, such as linagliptin and alogliptin.
• Production Methods: Chemical synthesis method involves the reaction of (R)-1-Boc-3-aminopiperidine with acetyl chloride to yield (R)-3-aminopiperidine dihydrochloride. The synthesis method involves several steps including salt formation, reduction, Hofmann degradation, chiral resolution, and hydrogenation.

Technology Process of (R)-3-Aminopiperidine dihydrochloride

There total 77 articles about (R)-3-Aminopiperidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3R)-1-benzyl-3-aminopiperidine (168466-84-0) → 3-(R)-aminopiperidine dihydrochloride (334618-23-4)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; at 40 ℃; for 24h;

Reference yield: 99.0%

(R)-piperidin-3-ylcarbamic acid tert-butyl ester (309956-78-3,172603-05-3) → 3-(R)-aminopiperidine dihydrochloride (334618-23-4)

Guidance literature:

With hydrogenchloride; In tert-butyl methyl ether; at 0 - 20 ℃; for 8h;

Reference yield: 96.5%

nipecotamide (4138-26-5,168749-30-2) → 3-amino-piperidine dihydrochloride (127294-75-1,138060-07-8,150395-91-8,334618-23-4)

Guidance literature:

nipecotamide; With tetrafluoroboric acid; 1-Fluoronaphthalene; dihydrogen peroxide;

With hydrogenchloride; In ethanol; water; for 0.5h;

upstream raw materials:

pyridin-3-ylamine

N-acetyl-3-aminopyridine acetate

N-acetyl-3-aminopiperidine acetate

nipecotamide

Downstream raw materials:

(S)-3-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoic acid (S)-3-aminopiperidine salt

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