Technology Process of Phosphoric acid diphenyl ester (6E,9Z)-(2R,4aR,11aS)-2-phenyl-4a,8,11,11a-tetrahydro-4H-1,3,5-trioxa-benzocyclononen-6-yl ester
There total 11 articles about Phosphoric acid diphenyl ester (6E,9Z)-(2R,4aR,11aS)-2-phenyl-4a,8,11,11a-tetrahydro-4H-1,3,5-trioxa-benzocyclononen-6-yl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hexamethylsilazane;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
at -78 ℃;
DOI:10.1021/ja971219p
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) LiHMDS / 1.) toluene, THF, 0 deg C, 20 min, 2.) toluene, THF, 0 deg C, 1 h; 25 deg C, 7 h
2: 82 percent / TBAF / tetrahydrofuran / 7 h / 25 °C
3: 87 percent / Dess-Martin reagent / CH2Cl2 / 4.5 h / 25 °C
4: 96 percent / NaClO2, NaH2PO4, 2-methyl-2-butene, H2O / tetrahydrofuran; 2-methyl-propan-2-ol / 3 h / 25 °C
5: Et3N / tetrahydrofuran / 0.33 h / 0 °C
6: DMAP / tetrahydrofuran; benzene / 1 h / 80 °C
7: 90 percent / KHMDS, HMPA / tetrahydrofuran; toluene / 1 h / -78 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; water; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 87 percent / Dess-Martin reagent / CH2Cl2 / 4.5 h / 25 °C
2: 96 percent / NaClO2, NaH2PO4, 2-methyl-2-butene, H2O / tetrahydrofuran; 2-methyl-propan-2-ol / 3 h / 25 °C
3: Et3N / tetrahydrofuran / 0.33 h / 0 °C
4: DMAP / tetrahydrofuran; benzene / 1 h / 80 °C
5: 90 percent / KHMDS, HMPA / tetrahydrofuran; toluene / 1 h / -78 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; water; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene; tert-butyl alcohol; benzene;
