2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ⁶,4λ⁶-[1,4]dithiin-2-yl)-ethylamine

Base Information

• Chemical Name: 2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ⁶,4λ⁶-[1,4]dithiin-2-yl)-ethylamine
• CAS No.: 289031-00-1
• Molecular Formula: C₁₂H₁₅NO₄S₂
• Molecular Weight: 301.387

Synonyms:2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ⁶,4λ⁶-[1,4]dithiin-2-yl)-ethylamine

Chemical Property of 2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ⁶,4λ⁶-[1,4]dithiin-2-yl)-ethylamine

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of 2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ⁶,4λ⁶-[1,4]dithiin-2-yl)-ethylamine

There total 3 articles about 2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ⁶,4λ⁶-[1,4]dithiin-2-yl)-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

[2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ6,4λ6-[1,4]dithiin-2-yl)-ethyl]-carbamic acid benzyl ester (289031-39-6) → 2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ6,4λ6-[1,4]dithiin-2-yl)-ethylamine (289031-00-1)

Guidance literature:

With tris(trifluoro acetyloxy)borane; trifluoroacetic acid; at 20 ℃; for 1h;

DOI:10.1016/S0968-0896(00)00062-6

Reference yield:

(S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]carbamic acid,phenylmethyl ester (26049-98-9) → 2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ6,4λ6-[1,4]dithiin-2-yl)-ethylamine (289031-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BF₃*Et₂O / tetrahydrofuran / 20 °C

1.2: pyridine / 2 h / 100 °C

2.1: 0.175 g / aq. H₂O₂ / acetic acid / 72 h / 20 °C

3.1: 18 percent / TFA; B(CF₃CO₂)3 / 1 h / 20 °C

With tris(trifluoro acetyloxy)borane; boron trifluoride diethyl etherate; dihydrogen peroxide; trifluoroacetic acid; In tetrahydrofuran; acetic acid; 1.1: Condensation / 1.2: Dehydrochlorination / 2.1: Oxidation / 3.1: Substitution;

DOI:10.1016/S0968-0896(00)00062-6

Reference yield:

[1-(5,6-dihydro-[1,4]dithiin-2-yl)-2-phenyl-ethyl]-carbamic acid benzyl ester (289031-38-5) → 2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ6,4λ6-[1,4]dithiin-2-yl)-ethylamine (289031-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.175 g / aq. H₂O₂ / acetic acid / 72 h / 20 °C

2: 18 percent / TFA; B(CF₃CO₂)3 / 1 h / 20 °C

With tris(trifluoro acetyloxy)borane; dihydrogen peroxide; trifluoroacetic acid; In acetic acid; 1: Oxidation / 2: Substitution;

DOI:10.1016/S0968-0896(00)00062-6

upstream raw materials:

[2-phenyl-1-(1,1,4,4-tetraoxo-1,4,5,6-tetrahydro-1λ⁶,4λ⁶-[1,4]dithiin-2-yl)-ethyl]-carbamic acid benzyl ester

(S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]carbamic acid,phenylmethyl ester

[1-(5,6-dihydro-[1,4]dithiin-2-yl)-2-phenyl-ethyl]-carbamic acid benzyl ester

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