methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

Base Information

• Chemical Name: methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid
• CAS No.: 88775-51-3
• Molecular Formula: C₂₁H₂₀O₈
• Molecular Weight: 400.385
• Mol file: 88775-51-3.mol

Synonyms:methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

Chemical Property of methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

There total 8 articles about methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (88775-49-9) + dimethyl sulfate (77-78-1) → methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (88775-51-3)

Guidance literature:

With potassium carbonate; In acetone; for 3h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85506-X

Reference yield:

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyramide (88775-41-1) → 3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) + 3,4,5-trimethoxybenzoylformic acid (88755-16-2) + methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (88775-51-3) + methyl 4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)-butyrate (88775-50-2)

Guidance literature:

With sodium hydroxide; potassium carbonate; dimethyl sulfate; Yield given. Multistep reaction. Yields of byproduct given; 1.) aq. EtOH, reflux, 10 h; 2.) acetone, rt., 4 h;

DOI:10.1248/cpb.31.3039

Reference yield:

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyramide (88775-41-1) + dimethyl sulfate (77-78-1) → 3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) + 3,4,5-trimethoxybenzoylformic acid (88755-16-2) + methyl (Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid (88775-51-3) + methyl 4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)-butyrate (88775-50-2)

Guidance literature:

With sodium hydroxide; potassium carbonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) aq. EtOH, reflux, 10 h; 2.) acetone, rt., 4 h;

DOI:10.1248/cpb.31.3039

upstream raw materials:

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyramide

(Z)-2-(3,4,5-trimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-4-oxo-2-butenoic acid

dimethyl sulfate

4-(3,4-methylenedioxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)butyronitrile