1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide

Base Information

Chemical Name:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide
CAS No.:1295298-11-1
Molecular Formula:C₂₁H₁₅BrFN₅O
Molecular Weight:452.285
Hs Code.:

Synonyms:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide

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Chemical Property of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide

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Technology Process of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide

There total 11 articles about 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220165-92-3
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid

: 1-(2-bromopyridin-4-yl)cyclopropylamine trifluoroacetate

: 1295298-11-1
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide

Guidance literature:: 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid; With HATU; In N,N-dimethyl-formamide; for 0.5h;

1-(2-bromopyridin-4-yl)cyclopropylamine trifluoroacetate; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 18h;

Reference yield:

: 118289-16-0
(2-bromopyridin-4-yl)methanol

: 1295298-11-1
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

1.2: 0 - 20 °C

2.1: ethanol; water / 72 h / 20 °C

3.1: sodium hydride / diethyl ether; dimethyl sulfoxide; mineral oil / 18 h / 20 °C / Cooling with water bath

4.1: diisobutylaluminium hydride / toluene / -78 - 20 °C

4.2: 20 °C

5.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; tert-butyl alcohol / 18 h / 20 °C

5.2: pH 2

6.1: triethylamine; diphenyl phosphoryl azide / 4 h / 90 °C / Sealed tube

7.1: dichloromethane / 18 h / 20 °C

8.1: HATU / N,N-dimethyl-formamide / 0.5 h

8.2: 18 h

With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; diphenyl phosphoryl azide; sodium hydride; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil; tert-butyl alcohol;

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 1295298-11-1
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid [1-(2-bromopyridin-4-yl)cyclopropyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-methyl-pyrrolidin-2-one / 2 h / 20 °C

1.2: 20 - 80 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -20 - -10 °C

2.3: 22 - 55 °C / pH 6 - 7

3.1: HATU / N,N-dimethyl-formamide / 0.5 h

3.2: 18 h

With isopropylmagnesium chloride; HATU; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;