6-Bromo-4-chloroquinazoline

Base Information

• Chemical Name: 6-Bromo-4-chloroquinazoline
• CAS No.: 38267-96-8
• Molecular Formula: C8H4BrClN2
• Molecular Weight: 243.49
• Hs Code.: 2933990090
• Mol file: 38267-96-8.mol

Synonyms:4-Chloro-6-bromoquinazoline;

Chemical Property of 6-Bromo-4-chloroquinazoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 160-163 °C
• Refractive Index: 1.691
• Boiling Point: 339.695 °C at 760 mmHg
• PKA: 0.07±0.30(Predicted)
• Flash Point: 159.242 °C
• PSA: 25.78000
• Density: 1.763 g/cm³
• LogP: 3.04570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-4-chloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Bromo-4-chloroquinazoline

There total 9 articles about 6-Bromo-4-chloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-bromo-4-hydroxyquinazoline (32084-59-6) → 6-bromo-4-chloroquinozoline (38267-96-8)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; for 4h; Reflux;

DOI:10.1016/j.bmcl.2017.03.020

Reference yield: 95.0%

6-bromoquinazolin-4(3H)-one (32084-59-6) → 6-bromo-4-chloroquinozoline (38267-96-8)

Guidance literature:

With trichlorophosphate; at 140 ℃; for 3h;

Reference yield: 18.0%

6-bromo-4-quinazolone (32084-59-6) → 6-bromo-4-chloroquinozoline (38267-96-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 100 ℃; for 2h;

upstream raw materials:

6-bromoquinazolin-4(3H)-one

5-bromoanthranilamide

5-Bromo-2-aminobenzoic acid

6-bromo-4-hydroxyquinazoline

Downstream raw materials:

6-bromo-N-(3-chloro-4-fluorophenyl)-4-quinazolinamine

methyl 3-[4-(6-bromo-4-quinazolinyl)piperazino]benzoate

methyl-{3-[4-(6-bromo-4-quinazolinyl)-1,4-diazepan-1-yl]phenyl}sulfone

6-Bromo-4-[4-(2-fluoro-5-methylsulfonylphenyl)piperazin-1-yl]quinazoline

Refernces

• 1、 Al Blooshi, Afra G.,Al Neyadi, Shaikha S.,Alnaqbi, Mohamed. A.,Nguyen, Ha L.. "UiO-66-NH2as an effective solid support for quinazoline derivatives for antibacterial agents against Gram-negative bacteria". supporting information. p. 20386 - 20395. Retrieved 2021/12/02.
• 2、 Chen, Zhe-Sheng,Dai, Qing-Qing,Li, Guo-Bo,Liu, Hong-Min,Liu, Hui,Wang, Bo,Wang, Shaomeng,Yu, Bin,Yuan, Shuo,Zhang, Jing-Ya,Zhang, Xiao-Nan,Zuo, Jia-Hui. "Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors". . p. 14895 - 14911. Retrieved 2021/10/12.