2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)acetic acid

Base Information

Chemical Name:2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)acetic acid
CAS No.:111104-25-7
Molecular Formula:C10H5Cl2NO4
Molecular Weight:274.06
Hs Code.:2925190090
European Community (EC) Number:879-042-4
DSSTox Substance ID:DTXSID10351873
Nikkaji Number:J501.912E
Wikidata:Q82128674
Mol file:111104-25-7.mol

Synonyms:111104-25-7;2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)acetic acid;(5,6-Dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid;2-(5,6-dichloro-1,3-dioxoisoindol-2-yl)acetic acid;(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid;ChemDiv3_002307;Oprea1_870355;AK-918/14939001;SCHEMBL14876139;DTXSID10351873;LHYSAUZLKMKURN-UHFFFAOYSA-N;HMS1479I19;2-(5,6-dichloro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetic acid;MFCD02189143;(5,6-DICHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETICACID;AKOS001047561;SB64791;CS-0219995;EN300-05498;A894794;SR-01000459930;J-501524;SR-01000459930-1;2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticacid;BRD-K40731816-001-01-9;Z56904581;5,6-Dichloro-1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid

Suppliers and Price of 2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticAcid
100mg
$ 90.00

TRC
2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticAcid
50mg
$ 45.00

Crysdot
2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticacid 95+%
5g
$ 677.00

Chemenu
2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticacid 95%
5g
$ 640.00

American Custom Chemicals Corporation
(5,6-DICHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID 95.00%
1G
$ 736.12

American Custom Chemicals Corporation
(5,6-DICHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID 95.00%
5G
$ 1210.63

American Custom Chemicals Corporation
(5,6-DICHLORO-1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ACETIC ACID 95.00%
2.5G
$ 1011.60

Alichem
2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticacid
5g
$ 745.56

AK Scientific
2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticacid
5g
$ 554.00

AK Scientific
2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticacid
500mg
$ 202.00

Total 13 raw suppliers

Chemical Property of 2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)acetic acid

Chemical Property:

Vapor Pressure:6.12E-11mmHg at 25°C
Boiling Point:503 °C at 760 mmHg
Flash Point:258 °C
PSA：74.68000
Density:1.727 g/cm³
LogP:1.61190
Storage Temp.:2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:272.9595630
Heavy Atom Count:17
Complexity:359

Purity/Quality:

97% ^*data from raw suppliers

2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C2C(=CC(=C1Cl)Cl)C(=O)N(C2=O)CC(=O)O

Technology Process of 2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)acetic acid

There total 2 articles about 2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 942-06-3
4,5-dichlorophthalic anhydride

: 56-40-6,18875-39-3,25718-94-9
glycine

: 111104-25-7
2-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)acetic acid?

Guidance literature:: In xylene; for 24h; Heating;
DOI:10.1055/s-1992-26234

Reference yield:

: 56962-08-4
4,5-dichlorophthalic acid

: 111104-25-7
2-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)acetic acid?

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Ac₂O / 2 h / Heating

2: 92 percent / xylene / 24 h / Heating

With acetic anhydride; In xylene;
DOI:10.1055/s-1992-26234

Reference yield:

: 111104-25-7
2-(5,6-dichloro-1,3-dioxoisoindolin-2-yl)acetic acid?

: 1431565-89-7
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5-methoxy-6-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 16 h / 0 - 20 °C

2.1: potassium nitrite / N,N-dimethyl-formamide / 5 h / Reflux

2.2: 20 °C

3.1: potassium hydrogencarbonate / water / 20 °C

4.1: N,N-dimethyl-formamide / 40 - 60 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 1 h / 775.74 Torr

6.1: pyridine / 31 h / 0 - 20 °C

7.1: hydrogenchloride / water; 1,4-dioxane / 20 °C

8.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 2 h / 20 °C

With pyridine; hydrogenchloride; dmap; potassium nitrite; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;