7-Bromo-4-chloroquinazoline

Base Information

• Chemical Name: 7-Bromo-4-chloroquinazoline
• CAS No.: 573675-55-5
• Molecular Formula: C8H4BrClN2
• Molecular Weight: 243.49
• Hs Code.: 2933990090
• Mol file: 573675-55-5.mol

Synonyms:quinazoline, 7-bromo-4-chloro-;

Chemical Property of 7-Bromo-4-chloroquinazoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.691
• Boiling Point: 339.695 °C at 760 mmHg
• PKA: 0.09±0.30(Predicted)
• Flash Point: 159.242 °C
• PSA: 25.78000
• Density: 1.763 g/cm³
• LogP: 3.04570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Bromo-4-chloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 41-25
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Bromo-4-chloroquinazoline

There total 5 articles about 7-Bromo-4-chloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-bromo-4-hydroxyquinazoline (194851-16-6) → 7-bromo-4-chloro-quinazoline (573675-55-5)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 95 ℃; for 9h;

Reference yield: 98.0%

7-bromoquinazolin-4(3H)-one (194851-16-6) → 7-bromo-4-chloro-quinazoline (573675-55-5)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; toluene; for 10h; Reflux;

DOI:10.1021/acs.jmedchem.1c01006

Reference yield:

2-amino-4-bromobenzoic acid (20776-50-5) → 7-bromo-4-chloro-quinazoline (573675-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 h / 170 °C

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 3 h / 115 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate;

upstream raw materials:

7-bromoquinazolin-4(3H)-one

7-bromo-4-hydroxyquinazoline

2-amino-4-bromobenzoic acid

2-amino-4-bromo-benzoic acid methyl ester

Downstream raw materials:

4-(4-chloroquinazolin-7-yl)morpholine

7-bromo-4-((4-methoxybenzyl)oxy)quinazoline

7-bromo-quinazolin-4-ylamine

Refernces

• 1、 -. "DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST". Paragraph 0181-0183. . Retrieved 2020/07/07.
• 2、 -. "HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS FOR THERAPEUTIC USES". Page/Page column 12; 16; 17. . Retrieved 2020/10/21.