sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

Base Information

Chemical Name:sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate
CAS No.:1186390-25-9
Molecular Formula:C₂₆H₁₈FN₆O₃*Na
Molecular Weight:504.455
Hs Code.:

Synonyms:sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

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Chemical Property of sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

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Technology Process of sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

There total 7 articles about sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186390-24-8
methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

: 1186390-25-9
sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

Guidance literature:: With methanol; sodium hydroxide; Reflux;

Reference yield:

: 174891-10-2
(5-amino-2H-pyrazol-3-yl)acetic acid

: 1186390-25-9
sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 2.5 h / 100 - 102 °C

2: 2-hydroxy-pyridine N-oxide; 3-methyl-N-(3-methylbutyl)-1-butanamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3: 18-crown-6 ether; cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C

4: methanol; sodium hydroxide / Reflux

With methanol; 2-hydroxy-pyridine N-oxide; 18-crown-6 ether; 3-methyl-N-(3-methylbutyl)-1-butanamine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 573675-55-5
7-bromo-4-chloro-quinazoline

: 1186390-25-9
sodium methyl 4-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1H-pyrazol-3-ylamino)quinazolin-7-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 2.5 h / 100 - 102 °C

2: 2-hydroxy-pyridine N-oxide; 3-methyl-N-(3-methylbutyl)-1-butanamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 - 25 °C

3: 18-crown-6 ether; cesium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C

4: methanol; sodium hydroxide / Reflux

With methanol; 2-hydroxy-pyridine N-oxide; 18-crown-6 ether; 3-methyl-N-(3-methylbutyl)-1-butanamine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;