1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester
• CAS No.: 844893-02-3
• Molecular Formula: C₂₈H₂₅F₂N₃O₅
• Molecular Weight: 521.52

Synonyms:1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester

Chemical Property of 1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester

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Technology Process of 1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester

There total 1 articles about 1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-cyclohexyl-2-(2-fluoro-4-hydroxyphenyl)-1H-benzimidazole-5-carboxylic acid methyl ester (501371-91-1) + (2-fluoro-5-nitrophenyl)methanol (63878-73-9) → 1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester (844893-02-3)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2007.03.027

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester (844893-02-3) → 1-cyclohexyl-2-[2-fluoro-4-(2-morpholin-4-yl-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester (844891-81-2)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2007.03.027

Reference yield: 61.0%

1-cyclohexyl-2-[2-fluoro-4-(2-fluoro-5-nitrobenzyloxy)phenyl]-1H-benzimidazole-5-carboxylic acid methyl ester (844893-02-3) + 1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one (943513-58-4) → 1-cyclohexyl-2-{2-fluoro-4-[2-[(2-methoxyethyl)methylamino]-5-(2-oxopyrrolidin-1-yl)benzyloxy]phenyl}-1H-benzimidazole-5-carboxylic acid methyl ester (943513-56-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2007.03.027

upstream raw materials:

1-cyclohexyl-2-(2-fluoro-4-hydroxyphenyl)-1H-benzimidazole-5-carboxylic acid methyl ester

(2-fluoro-5-nitrophenyl)methanol

Downstream raw materials:

C₃₄H₃₅FN₄O₇

C₃₃H₃₆FN₅O₅

C₃₄H₃₆FN₅O₆

C₃₄H₂₉ClFN₃O₆

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