1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one

Base Information

Chemical Name:1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one
CAS No.:943513-58-4
Molecular Formula:C₁₅H₂₂N₂O₃
Molecular Weight:278.351
Hs Code.:

Synonyms:1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one

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Chemical Property of 1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one

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Technology Process of 1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one

There total 5 articles about 1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 943513-32-4
4-chlorobutyric acid 5-(4-chlorobutyrylamino)-2-[(2-methoxyethyl)methylamino]benzyl ester

: 943513-58-4
1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one

Guidance literature:: With potassium hydroxide; In ethanol; water; at 80 ℃; for 2.5h;
DOI:10.1016/j.bmcl.2007.03.027

Reference yield:

: 943513-57-3
2-[(2-methoxyethyl)methylamino]-5-nitrobenzoic acid methyl ester

: 943513-58-4
1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / iron; NH₄Cl / tetrahydrofuran; methanol; H₂O / 3 h / 100 °C

2: 93 percent / LiAlH₄ / tetrahydrofuran / 7 h / 20 °C

3: 51 percent / AcONa; AcOH / tetrahydrofuran / 1.5 h / 20 °C

4: 87 percent / KOH / ethanol; H₂O / 2.5 h / 80 °C

With potassium hydroxide; lithium aluminium tetrahydride; sodium acetate; iron; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1016/j.bmcl.2007.03.027

Reference yield:

: 943513-30-2
5-amino-2-[(2-methoxyethyl)methylamino]benzoic acid methyl ester

: 943513-58-4
1-{3-hydroxymethyl-4-[(2-methoxyethyl)methylamino]phenyl}pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 7 h / 20 °C

2: 51 percent / AcONa; AcOH / tetrahydrofuran / 1.5 h / 20 °C

3: 87 percent / KOH / ethanol; H₂O / 2.5 h / 80 °C

With potassium hydroxide; lithium aluminium tetrahydride; sodium acetate; acetic acid; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmcl.2007.03.027