2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine

Base Information

Chemical Name:2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine
CAS No.:1197850-32-0
Molecular Formula:C₁₈H₁₂Cl₂N₄
Molecular Weight:355.226
Hs Code.:

Synonyms:2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine

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Chemical Property of 2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine

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Technology Process of 2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine

There total 4 articles about 2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1197849-66-3
6-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-4-ol

: 1197850-32-0
2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine

Guidance literature:: 6-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-4-ol; With trichlorophosphate; In acetonitrile; at 65 ℃; for 1h;

With sodium hydrogencarbonate; In ethyl acetate; acetonitrile;

Reference yield:

: 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride

: 1197850-32-0
2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / tetra-n-butylammonium cyanide / acetonitrile / 20 °C

2: potassium tert-butylate / acetonitrile / 20 °C

3: trifluoroacetic acid / water / 0.08 h / 150 °C / Microwave irradiation

4: trichlorophosphate / acetonitrile / 1 h / 65 °C

With potassium tert-butylate; trifluoroacetic acid; sodium iodide; trichlorophosphate; tetra-n-butylammonium cyanide; In water; acetonitrile;

Reference yield:

: 1197849-65-2
C₁₉H₁₁Cl₂N₅

: 1197850-32-0
2-(4-chlorophenyl)-3-((6-chloropyrimidin-4-yl)methyl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / water / 0.08 h / 150 °C / Microwave irradiation

2: trichlorophosphate / acetonitrile / 1 h / 65 °C

With trifluoroacetic acid; trichlorophosphate; In water; acetonitrile;