C₂₁H₂₆N₂O₅S

Base Information

Chemical Name:C₂₁H₂₆N₂O₅S
CAS No.:956219-57-1
Molecular Formula:C₂₁H₂₆N₂O₅S
Molecular Weight:418.514
Hs Code.:

C<sub>21</sub>H<sub>26</sub>N<sub>2</sub>O<sub>5</sub>S

Synonyms:C₂₁H₂₆N₂O₅S

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Chemical Property of C₂₁H₂₆N₂O₅S

Chemical Property:

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Technology Process of C₂₁H₂₆N₂O₅S

There total 15 articles about C₂₁H₂₆N₂O₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 217175-29-6
(3R,3aS,6aS,9R,9aS)-9-Hydroxy-3-(2-methyl-allyl)-6-(toluene-4-sulfonyl)-octahydro-7-oxa-1,6-diaza-cyclopenta[d]indene-1-carboxylic acid tert-butyl ester

: 956219-57-1
C₂₁H₂₆N₂O₅S

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1021/jo9817117

Reference yield:

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 956219-57-1
C₂₁H₂₆N₂O₅S

Guidance literature:: Multi-step reaction with 15 steps

1.1: Ph₃P; DEAD / tetrahydrofuran

2.1: n-BuLi / diethyl ether

3.1: H₂ / Pd/CaCO₃/Pb / toluene

4.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,2-dimethoxy-ethane / -78 °C

4.2: 71 percent / tetrahydrofuran; 1,2-dimethoxy-ethane / -78 °C

5.1: 69 percent / dimethylsulfoxide / 180 °C

6.1: 91 percent / Me₃Al / toluene

7.1: LHMDS / tetrahydrofuran / -78 °C

7.2: 79 percent / N,N-dimethylpropylene urea / tetrahydrofuran / -78 °C

8.1: 75 percent / aq. HCl / tetrahydrofuran

9.1: 98 percent / DMAP / acetonitrile

10.1: DIBALH / CH₂Cl₂ / -78 °C

11.1: NaCNBH₃ / acetic acid

12.1: TBAF / tetrahydrofuran

13.1: K₂CO₃ / methanol

14.1: DIBALH / CH₂Cl₂ / -78 °C

14.2: 78 percent / aq. HCl

15.1: 90 percent / sodium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

With hydrogenchloride; dmap; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; trimethylaluminum; sodium hexamethyldisilazane; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; Lindlar's catalyst; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; acetic acid; dimethyl sulfoxide; toluene; acetonitrile; 1.1: Alkylation / 2.1: Acylation / 3.1: Catalytic hydrogenation / 4.1: Metallation / 4.2: Michael addition / 5.1: Elimination / 6.1: Cyclization / 7.1: Metallation / 7.2: Alkylation / 8.1: Hydrolysis / 9.1: Acylation / 10.1: Reduction / 11.1: Reduction / 12.1: desilylation / 13.1: Cyclization / 14.1: Reduction / 14.2: Cyclization / 15.1: Cyclization;
DOI:10.1021/jo9817117

Reference yield:

: 338463-00-6
N-(tert-butoxycarbonyl)-N-but-3-ynyl-4-methylbenzenesulfonamide

: 956219-57-1
C₂₁H₂₆N₂O₅S

Guidance literature:: Multi-step reaction with 14 steps

1.1: n-BuLi / diethyl ether

2.1: H₂ / Pd/CaCO₃/Pb / toluene

3.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,2-dimethoxy-ethane / -78 °C

3.2: 71 percent / tetrahydrofuran; 1,2-dimethoxy-ethane / -78 °C

4.1: 69 percent / dimethylsulfoxide / 180 °C

5.1: 91 percent / Me₃Al / toluene

6.1: LHMDS / tetrahydrofuran / -78 °C

6.2: 79 percent / N,N-dimethylpropylene urea / tetrahydrofuran / -78 °C

7.1: 75 percent / aq. HCl / tetrahydrofuran

8.1: 98 percent / DMAP / acetonitrile

9.1: DIBALH / CH₂Cl₂ / -78 °C

10.1: NaCNBH₃ / acetic acid

11.1: TBAF / tetrahydrofuran

12.1: K₂CO₃ / methanol

13.1: DIBALH / CH₂Cl₂ / -78 °C

13.2: 78 percent / aq. HCl

14.1: 90 percent / sodium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

With hydrogenchloride; dmap; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; trimethylaluminum; sodium hexamethyldisilazane; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; lithium hexamethyldisilazane; Lindlar's catalyst; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; acetic acid; dimethyl sulfoxide; toluene; acetonitrile; 1.1: Acylation / 2.1: Catalytic hydrogenation / 3.1: Metallation / 3.2: Michael addition / 4.1: Elimination / 5.1: Cyclization / 6.1: Metallation / 6.2: Alkylation / 7.1: Hydrolysis / 8.1: Acylation / 9.1: Reduction / 10.1: Reduction / 11.1: desilylation / 12.1: Cyclization / 13.1: Reduction / 13.2: Cyclization / 14.1: Cyclization;
DOI:10.1021/jo9817117