2-(2-Bromoacetyl)thiophene

Base Information

• Chemical Name: 2-(2-Bromoacetyl)thiophene
• CAS No.: 10531-41-6
• Molecular Formula: C6H5BrOS
• Molecular Weight: 205.075
• Hs Code.: 29349990
• European Community (EC) Number: 638-953-5
• DSSTox Substance ID: DTXSID30380024
• Nikkaji Number: J947.663F
• Wikidata: Q72451342
• Mol file: 10531-41-6.mol

Synonyms:Ketone,bromomethyl 2-thienyl (7CI,8CI);(a-Bromoacetyl)thiophene;2-(Bromoacetyl)thiophene;2-Bromo-1-(2-thienyl)ethan-1-one;2-Bromo-1-thien-2-ylethanone;2-Bromo-1-thiophen-2-ylethanone;Bromomethyl2-thienyl ketone;Bromomethyl a-thienyl ketone;a-Bromo-2-acetylthiophene;Ethanone,2-bromo-1-(2-thienyl)-;

Chemical Property of 2-(2-Bromoacetyl)thiophene

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00764mmHg at 25°C
• Melting Point: 29-33 °C(lit.)
• Refractive Index: 1.601
• Boiling Point: 268.55 °C at 760 mmHg
• Flash Point: 116.215 °C
• PSA: 45.31000
• Density: 1.659 g/cm³
• LogP: 2.32570
• Storage Temp.: Keep Cold
• Sensitive.: Stench
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 203.92445
• Heavy Atom Count: 9
• Complexity: 116

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Bromoacetyl)thiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, T
• Hazard Codes: C,T
• Statements: 22-34-43
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C(=O)CBr

Technology Process of 2-(2-Bromoacetyl)thiophene

There total 13 articles about 2-(2-Bromoacetyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Acetylthiophene (88-15-3,97511-16-5) → 2-Bromoacetylthiophene (10531-41-6)

Guidance literature:

With copper(ll) bromide; In ethyl acetate; at 85 ℃; for 24h;

DOI:10.1039/c9md00365g

Reference yield: 97.3%

2-Acetylthiophene (88-15-3,97511-16-5) + copper(II)bromide (7789-45-9) → 2-Bromoacetylthiophene (10531-41-6)

Guidance literature:

In chloroform; ethyl acetate;

Reference yield: 72.0%

2-Acetylthiophene (88-15-3,97511-16-5) → 2-Bromoacetylthiophene (10531-41-6) + 2,2-dibromo-1-(thiophen-2-yl)ethan-1-one (68672-88-8)

Guidance literature:

With 1-methyl-3-(4-sulfonylbutyl)-1H-imidazol-3-ium trifluoromethanesulfonate; N-Bromosuccinimide; at 55 ℃; for 0.166667h; Green chemistry;

DOI:10.3390/molecules18010074

upstream raw materials:

2-Acetylthiophene

bromocyane

Ethyl thiophene-2-carboxylate

1,1-dibromomethane

Downstream raw materials:

2-[4-(2-thienyl)-1,3-thiazol-2-yl]ethanenitrile

(phenyl-hydrazono)-(4-thiophen-2-yl-thiazol-2-yl)-acetonitrile