1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile

Base Information

• Chemical Name: 1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile
• CAS No.: 101605-23-6
• Molecular Formula: C₁₈H₁₃NO₂
• Molecular Weight: 275.307
• Mol file: 101605-23-6.mol

Synonyms:1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile

Chemical Property of 1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile

There total 2 articles about 1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-[dimethyl(oxo)-λ6-sulfaneylidene]-1-(4-methoxyphenyl)ethan-1-one + Benzoylacetonitrile (614-16-4) → 1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile (101605-23-6)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In 1,2-dichloro-ethane; at 50 ℃; for 6h;

DOI:10.1002/adsc.201800362

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) → 1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile (101605-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / Inert atmosphere; Darkness; Reflux

1.2: 1 h / 0 °C / Inert atmosphere

2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate / 1,2-dichloro-ethane / 6 h / 50 °C

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium tert-butylate; cesium acetate; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1002/adsc.201800362

Reference yield: 55.0%

1-hydroxy-3-(4-methoxyphenyl)-2-naphthonitrile (101605-23-6) + diphenyl acetylene (501-65-5) → 8-(4-methoxyphenyl)-2,3-diphenylbenzo[de]chromene-9-carbonitrile

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; oxygen; copper(II) acetate monohydrate; In toluene; at 100 ℃; for 12h; under 760.051 Torr; Schlenk technique;

DOI:10.1002/adsc.201800362

upstream raw materials:

Benzoylacetonitrile

4-methoxy-benzoyl chloride

Downstream raw materials:

1-methoxy-3-(4-methoxy-phenyl)-[2]naphthonitrile