5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine

Base Information

• Chemical Name: 5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine
• CAS No.: 110526-61-9
• Molecular Formula: C₁₀H₁₇N₅O₅
• Molecular Weight: 287.275
• Mol file: 110526-61-9.mol

Synonyms:5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine

Chemical Property of 5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine

There total 1 articles about 5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-methoxy adenosine (71724-30-6) → N6-methoxyadenosine (19399-25-8) + 5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine (110526-61-9)

Guidance literature:

With sodium hydroxide; for 0.25h; Heating;

DOI:10.1248/cpb.39.301

Reference yield:

5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine (110526-61-9) → adenosine (58-61-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂; 1N aq. HCl / Raney Ni W-2 / H₂O / 2.5 h / 26 °C / 760 Torr

2: Amberlite IRA-402 (OH-) / H₂O

3: dimethylformamide / 4 h / 24 °C

With hydrogenchloride; Amberlite IRA-402 (OH-); hydrogen; Raney Ni W-2; In water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.301

Reference yield:

5-Amino-N'-methoxy-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine (110526-61-9) → adenosine 1-oxide (146-92-9,7013-17-4,14215-95-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / H₂; 1N aq. HCl / Raney Ni W-2 / H₂O / 2.5 h / 26 °C / 760 Torr

2: Amberlite IRA-402 (OH-) / H₂O

3: dimethylformamide / 4 h / 24 °C

4: 81 percent / m-chloroperbenzoic acid / methanol / 7 h / 30 °C

With hydrogenchloride; Amberlite IRA-402 (OH-); hydrogen; 3-chloro-benzenecarboperoxoic acid; Raney Ni W-2; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.301

upstream raw materials:

1-methoxy adenosine

Downstream raw materials:

Adenosine-2-d

adenosine 1-oxide

5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamidine

adenosine

Refernces