2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene

Base Information

Chemical Name:2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene
CAS No.:1453393-50-4
Molecular Formula:C₁₅H₂₀F₄N₂O₃
Molecular Weight:352.329
Hs Code.:

Synonyms:2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene

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Chemical Property of 2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene

Chemical Property:

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Technology Process of 2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene

There total 5 articles about 2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1453393-39-9
1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

: 1453393-50-4
2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene

Guidance literature:: With pyridine; tin(II) chloride dihdyrate; In ethyl acetate; at 20 ℃; for 6h;
DOI:10.1039/c3md00110e

Reference yield:

: 400-70-4
2,4-dichloro-5-nitrobenzotrifluoride

: 1453393-50-4
2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia / 1,4-dioxane / 144 h / 100 °C / Sealed tube

2: potassium carbonate / dimethyl sulfoxide / 72 h / 90 °C

3: triethylamine; dmap / dichloromethane / 18 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

5: tin(II) chloride dihdyrate; pyridine / ethyl acetate / 6 h / 20 °C

With pyridine; dmap; tin(II) chloride dihdyrate; ammonia; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1039/c3md00110e

Reference yield:

: 35375-74-7
5-chloro-2-nitro-4-(trifluoromethyl)aniline

: 1453393-50-4
2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 72 h / 90 °C

2: triethylamine; dmap / dichloromethane / 18 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

4: tin(II) chloride dihdyrate; pyridine / ethyl acetate / 6 h / 20 °C

With pyridine; dmap; tin(II) chloride dihdyrate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1039/c3md00110e