1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

Base Information

• Chemical Name: 1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene
• CAS No.: 1453393-39-9
• Molecular Formula: C₁₅H₁₈F₄N₂O₅
• Molecular Weight: 382.312

Synonyms:1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

Chemical Property of 1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

Chemical Property:

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Technology Process of 1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

There total 4 articles about 1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene (1453393-84-4) → 1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene (1453393-39-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1039/c3md00110e

Reference yield:

2,4-dichloro-5-nitrobenzotrifluoride (400-70-4) → 1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene (1453393-39-9)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia / 1,4-dioxane / 144 h / 100 °C / Sealed tube

2: potassium carbonate / dimethyl sulfoxide / 72 h / 90 °C

3: triethylamine; dmap / dichloromethane / 18 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With dmap; ammonia; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

DOI:10.1039/c3md00110e

Reference yield:

5-chloro-2-nitro-4-(trifluoromethyl)aniline (35375-74-7) → 1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene (1453393-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 72 h / 90 °C

2: triethylamine; dmap / dichloromethane / 18 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With dmap; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/c3md00110e

upstream raw materials:

2,4-dichloro-5-nitrobenzotrifluoride

5-chloro-2-nitro-4-(trifluoromethyl)aniline

5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)aniline

1-[bis(tert-butoxycarbonyl)amino]-5-(3’-fluoropropoxy)-2-nitro-4-(trifluoromethyl)benzene

Downstream raw materials:

2-amino-1-(tert-butoxycarbonylamino)-5-(3’-fluoropropoxy)-4-(trifluoromethyl)benzene

7-(3'''-fluoropropoxy)-4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

1-(tert-butoxycarbonylamino)-5-(3''''fluoropropoxy)-2-{3’-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3’-oxopropanamido}-4-(trifluoromethyl)benzene

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