[(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane

Base Information

Chemical Name:[(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane
CAS No.:943987-67-5
Molecular Formula:C₂₁H₃₆O₂Si
Molecular Weight:348.601
Hs Code.:

Synonyms:[(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane

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Chemical Property of [(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane

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Technology Process of [(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane

There total 5 articles about [(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 943987-66-4
(2R,3S)-5-benzyloxy-3-(tert-butyldimethylsilanyloxy)-2-ethylpentanal

: 1779-49-3
Methyltriphenylphosphonium bromide

: 943987-67-5
[(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane

Guidance literature:: Methyltriphenylphosphonium bromide; With tert.-butyl lithium; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

(2R,3S)-5-benzyloxy-3-(tert-butyldimethylsilanyloxy)-2-ethylpentanal; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1002/chem.200601672

Reference yield:

: 943987-65-3
[(2S,3S)-5-benzyloxy-3-(tert-butyldimethylsilanyloxy)-2-ethylpent-(E)-ylidene][(R)-2-methoxymethylpyrrolidin-1-yl]amine

: 943987-67-5
[(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / magnesium monoperoxyphthalate hexahydrate / methanol / 6 h / 0 °C / pH 7

2.1: 86 percent / diisobutylaluminium hydride / tetrahydrofuran; heptane / 2 h / 0 °C

3.1: t-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C

3.2: 97 percent / tetrahydrofuran / -78 - 20 °C

With tert.-butyl lithium; diisobutylaluminium hydride; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; methanol; n-heptane;
DOI:10.1002/chem.200601672

Reference yield:

: 943987-78-8
C₂₀H₃₃NO₂Si

: 943987-67-5
[(1S,2S)-1-(2-benzyloxyethyl)-2-ethyl-but-3-enyloxy]-tert-butyldimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / diisobutylaluminium hydride / tetrahydrofuran; heptane / 2 h / 0 °C

2.1: t-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C

2.2: 97 percent / tetrahydrofuran / -78 - 20 °C

With tert.-butyl lithium; diisobutylaluminium hydride; In tetrahydrofuran; n-heptane;
DOI:10.1002/chem.200601672