Biphenyl-2-YL-phenyl-methanol

Base Information

• Chemical Name: Biphenyl-2-YL-phenyl-methanol
• CAS No.: 30469-82-0
• Molecular Formula: C₁₉H₁₆O
• Molecular Weight: 260.335
• European Community (EC) Number: 653-283-3
• Nikkaji Number: J408.812C
• Mol file: 30469-82-0.mol

Synonyms:BIPHENYL-2-YL-PHENYL-METHANOL;alpha-Phenylbiphenyl-2-methanol;SCHEMBL3278303;AKOS024323821

Chemical Property of Biphenyl-2-YL-phenyl-methanol

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 260.120115130
• Heavy Atom Count: 20
• Complexity: 276

Purity/Quality:

BIPHENYL-2-YL-PHENYL-METHANOL Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC=C2C(C3=CC=CC=C3)O

Technology Process of Biphenyl-2-YL-phenyl-methanol

There total 19 articles about Biphenyl-2-YL-phenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Phenylbenzaldehyde (1203-68-5) + phenylboronic acid (98-80-6) → α-phenyl[1,1'-biphenyl]-2-methanol (30469-82-0)

Guidance literature:

With 1-(2,6-diisopropylphenyl)-3-(2-(phenylthio)phenyl)-4,5-dihydroimidazolinium chloride; bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; In water; at 20 - 100 ℃;

DOI:10.1016/j.tet.2010.06.049

Reference yield: 90.0%

2-Bromobiphenyl (2052-07-5) + benzaldehyde (100-52-7) → α-phenyl[1,1'-biphenyl]-2-methanol (30469-82-0)

Guidance literature:

2-Bromobiphenyl; With TurboGrignard; In tetrahydrofuran; at 20 ℃; for 24h;

benzaldehyde; In tetrahydrofuran; at 0 ℃; for 0.333333h;

DOI:10.1002/anie.200454084

Reference yield: 82.0%

bromobenzene (108-86-1,52753-63-6) + 2-Phenylbenzaldehyde (1203-68-5) → α-phenyl[1,1'-biphenyl]-2-methanol (30469-82-0)

Guidance literature:

bromobenzene; With magnesium; In tetrahydrofuran;

2-Phenylbenzaldehyde; In tetrahydrofuran; at 20 ℃; for 1h; Further stages.;

DOI:10.1016/j.tet.2008.07.021

upstream raw materials:

2-phenylbenzophenone

benzaldehyde

biphenyl-2-ylmagnesium iodide

[1,1′-biphenyl]-2-yldimethylphosphine oxide

Downstream raw materials:

2-(Biphenyl-2-yl-phenyl-methoxy)-N,N-dimethyl-acetamide

2-fluorobiphenyl

2-(α-chlorophenylmethyl)biphenyl

2-phenylbenzhydryl bromide