N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide

Base Information

Chemical Name:N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide
CAS No.:572875-44-6
Molecular Formula:C₂₆H₂₃ClN₂O₃
Molecular Weight:446.933
Hs Code.:

Synonyms:N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide

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Chemical Property of N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide

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Technology Process of N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide

There total 4 articles about N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: 100-46-9
benzylamine

: 572875-44-6
N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide

Guidance literature:: With zirconium(IV) chloride; In tetrahydrofuran; at 70 ℃; for 24h; Molecular sieve; Inert atmosphere;
DOI:10.1002/chem.201104055

Reference yield: 86.0%

: C₁₉H₂₀N₂O₂

: 74-11-3
para-chlorobenzoic acid

: 572875-44-6
N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide

Guidance literature:: para-chlorobenzoic acid; solid phase supported [2-iodo-5-[3-(3-phenylpropanoylamino)propoxy]phenyl]boronic acid; In dichloromethane; at 25 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

C₁₉H₂₀N₂O₂; In dichloromethane; at 25 ℃; for 48h; Molecular sieve; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.06.043

Reference yield: 85.0%

: C₁₉H₂₀N₂O₂

: 74-11-3
para-chlorobenzoic acid

: 572875-44-6
N-benzyl-2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetamide

Guidance literature:: para-chlorobenzoic acid; With (2-iodo-5-methoxyphenyl)boronic acid; In dichloromethane; at 25 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

C₁₉H₂₀N₂O₂; In toluene; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo3013258 DOI:10.1021/jo3013258