2-AMINO CYCLOPENTANOL

Base Information

• Chemical Name: 2-AMINO CYCLOPENTANOL
• CAS No.: 89381-13-5
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• Hs Code.: 2922199090
• Mol file: 89381-13-5.mol

Synonyms:1-Amino-2-hydroxycyclopentane;2-Aminocyclopentanol;2-Hydroxycyclopentylamine;Cyclopentanol, trans-2-amino-;

Chemical Property of 2-AMINO CYCLOPENTANOL

Chemical Property:

• Refractive Index: 1.4965 (589.3 nm 15℃)
• Boiling Point: 179.4 °C at 760 mmHg
• PKA: 14.93±0.40(Predicted)
• Flash Point: 62.3 °C
• PSA: 46.25000
• Density: 1.084 g/cm³
• LogP: 0.55880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Aminocyclopentanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO CYCLOPENTANOL

There total 38 articles about 2-AMINO CYCLOPENTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(1S,2S)-trans-2-(N-benzyl)amino-1-cyclopentanol (1033605-25-2) → (1S,2S)-2-aminocyclopentanol (930-45-0,33092-86-3,33092-90-9,57070-95-8,59260-76-3,68327-03-7,89381-13-5,135969-63-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; under 760 Torr;

DOI:10.1021/jo052433w

Reference yield: 90.0%

(1S,2S)-2-(benzyloxy)cyclopentanamine (181657-56-7,404028-21-3,796038-32-9,181657-57-8) → (1S,2S)-2-aminocyclopentanol (930-45-0,33092-86-3,33092-90-9,57070-95-8,59260-76-3,68327-03-7,89381-13-5,135969-63-0)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; at 25 ℃; for 14h;

Reference yield: 88.0%

(1S,2S)-trans-2-<(R)-(α-methylbenzyl)amino>cyclopentanol hydrochloride → (1S,2S)-2-aminocyclopentanol (930-45-0,33092-86-3,33092-90-9,57070-95-8,59260-76-3,68327-03-7,89381-13-5,135969-63-0)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In N,N-dimethyl-formamide; at 110 - 120 ℃; for 4h;

DOI:10.1021/jo00221a036

upstream raw materials:

trans-2-aminocyclopentanol

1-azido-2-(trimethylsilyloxy)cyclopentane

benzyl (1S,2S)-trans-N-(2-hydroxycyclopentyl)carbamate

(1S,2S)-trans-2-azidocyclopentanol

Downstream raw materials:

(1S,2S)-trans-2-(tert-butoxycarbonylamino)cyclopentanol

(1S,2S)-2-aminocyclopentanol hydrochloride

(1R,2S)-2-tert-Butoxycarbonylaminocyclopentylamine

(S,S)-trans-2-acetamidocyclopentanol