(1S,2S)-trans-2-azidocyclopentanol

Base Information

• Chemical Name: (1S,2S)-trans-2-azidocyclopentanol
• CAS No.: 125356-51-6
• Molecular Formula: C₅H₉N₃O
• Molecular Weight: 127.146
• Mol file: 125356-51-6.mol

Synonyms:(1S,2S)-trans-2-azidocyclopentanol

Chemical Property of (1S,2S)-trans-2-azidocyclopentanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S,2S)-trans-2-azidocyclopentanol

There total 9 articles about (1S,2S)-trans-2-azidocyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1S,2S)-2-azido-cyclopentyl butyrate (756874-86-9) → (1S,2S)-trans-2-azidocyclopentanol (125356-51-6,88807-02-7)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1021/jo049442+

Reference yield: 94.0%

Cyclopentene oxide (285-67-6) → (1S,2S)-trans-2-azidocyclopentanol (125356-51-6,88807-02-7)

Guidance literature:

With sodium azide; ammonium chloride; In methanol; water; at 60 ℃; for 13h;

Reference yield: 49.0%

(±)-trans-2-azidocyclopentanol (88807-02-7) → (1S,2S)-trans-2-azidocyclopentanol (125356-51-6,88807-02-7) + (1R,2R)-trans-2-azidocyclopentyl acetate (260065-68-7)

Guidance literature:

With Isopropenyl acetate; lipase Amano AK-20; In tert-butyl methyl ether; at 20 ℃; for 72h; Inert atmosphere; Enzymatic reaction;

DOI:10.1021/jm400529f

upstream raw materials:

Cyclopentene oxide

vinyl acetate

(±)-trans-2-azidocyclopentanol

(1S,2S)-2-azido-cyclopentyl butyrate

Downstream raw materials:

(1S,2S)-2-aminocyclopentanol

(1S,2S)-trans-2-(tert-butoxycarbonylamino)cyclopentanol

(1R,2S)-2-tert-Butoxycarbonylaminocyclopentylamine

(1R,2S)-cis-2-azidocyclopentanol