4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester

Base Information

Chemical Name:4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester
CAS No.:1350439-68-7
Molecular Formula:C₅₄H₅₉N₅O₉S
Molecular Weight:954.157
Hs Code.:

4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester

Synonyms:4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester

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Chemical Property of 4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester

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Technology Process of 4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester

There total 5 articles about 4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350439-67-6
4'-[6-(4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid t-butyl ester

: 179087-93-5
[4-[[2,4-dioxo-1,3-thiazolidine-5-yl]methyl]phenoxy]acetic acid

: 1350439-68-7
4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

: 1092951-05-7
6-hydroxymethyl-4-methyl-2-propyl-1H-benzimidazole

: 1350439-68-7
4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.22 h / Cooling with ice

2.2: 72 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 0.2 h

4.1: diethyl cyanophosphonate; triethylamine / tetrahydrofuran / 48 h / 20 °C

With diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1190092-28-4
4'-(6-hydroxymethyl-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

: 1350439-68-7
4'-{6-(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethylcarbonylamino]phenoxymethyl)-4-methyl-2-propyl-1H-benzimidazol-1-ylmethyl}biphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.22 h / Cooling with ice

1.2: 72 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 0.2 h

3.1: diethyl cyanophosphonate; triethylamine / tetrahydrofuran / 48 h / 20 °C

With diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;