7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 152628-00-7
• Molecular Formula: C13H16N2O2
• Molecular Weight: 232.282
• Hs Code.: 2933990090
• Mol file: 152628-00-7.mol

Synonyms:2-Propyl-4-methyl-1H-benzimidazole-6-carboxylicacid methyl ester;4-Methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methylester;Methyl 7-methyl-2-propyl-5-benzimidazolecarboxylate;

Chemical Property of 7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.594
• Boiling Point: 434.22 °C at 760 mmHg
• PKA: 11.26±0.30(Predicted)
• Flash Point: 216.408 °C
• PSA: 54.98000
• Density: 1.17g/cm³
• LogP: 2.61040

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-2-propyl-1H-benzimidazole-6-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER

There total 10 articles about 7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester (152628-01-8) → 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester (152628-00-7)

Guidance literature:

With sodium dithionite; In water; at 70 - 100 ℃; Product distribution / selectivity;

Reference yield: 94.2%

methanol (67-56-1) + 2-n-propyl-4-methylbenzimidazol-6-carboxylic acid hydrochloride (1158998-60-7) → 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester (152628-00-7)

Guidance literature:

methanol; 2-n-propyl-4-methylbenzimidazol-6-carboxylic acid hydrochloride; With thionyl chloride; at 10 ℃; Reflux;

With sodium carbonate; In water; pH=~ 9;

Reference yield: 90.0%

3-methyl-4-butyrylamino-5-aminobenzoic acid methyl ester (675882-71-0) → 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester (152628-00-7)

Guidance literature:

In acetic acid; for 2h; Heating;

DOI:10.1002/jhet.5570400623

upstream raw materials:

3-methyl-4-butyrylamino-5-aminobenzoic acid methyl ester

3-methyl-4-nitrobenzoic acid

methyl 4-amino-3-methylbenzoate

methyl 3-methyl-4-nitrobenzoate

Downstream raw materials:

4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carbonitrile

4'-[[2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)-benzimidazol-1-yl]methyl]-2-cyanobiphenyl

methyl 4'-[[2-n-propyl-4-methyl-6-(5-methylbenzoxazol-2-yl)-benzimidazol-1-yl]methyl]biphenyl-2-carboxylate

4'-[4-methyl-6-(7-methyl-benzooxazol-2-yl)-2-propyl-benzoimidazol-1-ylmethyl]-biphenyl-2-carboxylic acid methyl ester