methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate

Base Information

• Chemical Name: methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate
• CAS No.: 77265-64-6
• Molecular Formula: C₁₉H₂₁ClN₂O₃
• Molecular Weight: 360.84
• Mol file: 77265-64-6.mol

Synonyms:methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate

Chemical Property of methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate

There total 2 articles about methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-anthranilic acid hydrochloride (209533-97-1) → methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate (77265-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 22 percent / Cl₂, AcOH / CHCl₃; methanol / 0.5 h / 0 °C

2: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 2 h, 2.) THF, RT, overnight

With chlorine; acetic acid; 1,1'-carbonyldiimidazole; In methanol; chloroform;

DOI:10.1021/jm9810349

Reference yield:

4-(2-amino-ethyl)-benzoic acid methyl ester (77265-67-9) + 5-chloro-2-dimethylamio-benzoic acid (77265-65-7) → methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate (77265-64-6)

Guidance literature:

With 1,1'-carbonyldiimidazole; Yield given; Multistep reaction; 1.) THF, RT, 2 h, 2.) THF, RT, overnight;

DOI:10.1021/jm9810349

Reference yield: 70.0%

methyl 4-(2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl)-benzoate (77265-64-6) → 4-[2-(5-chloro-2-dimethylamino-benzoylamino)-ethyl]-benzoic acid

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; methanol; Ambient temperature;

DOI:10.1021/jm9810349

upstream raw materials:

4-(2-amino-ethyl)-benzoic acid methyl ester

5-chloro-2-dimethylamio-benzoic acid

N,N-dimethyl-anthranilic acid hydrochloride