(E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine

Base Information

Chemical Name:(E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine
CAS No.:1430968-17-4
Molecular Formula:C₂₁H₂₄N₄O₂S
Molecular Weight:396.513
Hs Code.:

Synonyms:(E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine

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Technology Process of (E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine

There total 2 articles about (E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₆N₄

: 98-59-9
p-toluenesulfonyl chloride

: 1430968-17-4
(E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine

Guidance literature:: C₁₃H₁₆N₄; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

p-toluenesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol400137q

Reference yield:

: C₁₈H₂₄N₄O₂

: 1430968-17-4
(E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol400137q

Reference yield:

: 1422192-33-3
(S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

: 1430968-17-4
(E)-2-[2-(2-azido-5-methylphenyl)-1-methylvinyl]-1-(toluene-4-sulfonyl)pyrrolidine

: 3-(2-benzenesulfonylpyrrolidin-1-yl)-2-methyl-1H-indole

: 1430972-59-0
2,5-dimethyl-3-[1-(toluene-4-sulfonyl)pyrrolidin-2-yl]-1H-indole

Guidance literature:: With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; In benzene; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol400137q