(S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

Base Information

Chemical Name:(S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine
CAS No.:1422192-33-3
Molecular Formula:C₁₉H₂₀N₄O₂S
Molecular Weight:368.459
Hs Code.:

Synonyms:(S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

Suppliers and Price of (S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

There total 9 articles about (S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₆N₄

: 98-09-9
benzenesulfonyl chloride

: 1422192-33-3
(S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

Guidance literature:: C₁₃H₁₆N₄; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

benzenesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol400137q

Reference yield:

: C₁₂H₂₃NO₃

: 1422192-33-3
(S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

2.2: 15 h / Inert atmosphere

3.1: sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

4.1: 2-Methyl-2-nitropropane; trimethylsilylazide / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

6.2: 2 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2-Methyl-2-nitropropane; trimethylsilylazide; silica gel; triethylamine; pyridinium chlorochromate; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; 3.1: |Suzuki Coupling;
DOI:10.1021/ol400137q

Reference yield:

: (S)-2-(1-methyl-2-oxoethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1422192-33-3
(S)-E-2-[2-(2-azido-phenyl)-1-methylvinyl]-1-benzenesulfonylpyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

1.2: 15 h / Inert atmosphere

2.1: sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 12 h / 120 °C / Inert atmosphere

3.1: 2-Methyl-2-nitropropane; trimethylsilylazide / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

5.2: 2 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2-Methyl-2-nitropropane; trimethylsilylazide; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; 2.1: |Suzuki Coupling;
DOI:10.1021/ol400137q