Technology Process of (E)-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenyl diethyl phosphate
There total 6 articles about (E)-5-((2,4,6-trimethoxystyrylsulfonyl)methyl)-2-methoxyphenyl diethyl phosphate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ON-013105;
With
carbon tetrabromide; triethylamine;
In
acetonitrile;
at 0 - 20 ℃;
for 0.166667h;
phosphonic acid diethyl ester;
In
acetonitrile;
at 0 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: carbon tetrabromide; triethylamine / acetonitrile / 0.17 h / 0 °C
1.2: 2 h / 0 °C
2.1: trimethylsilyl bromide / dichloromethane / 0.75 h / 0 °C
3.1: carbon tetrabromide; triethylamine / acetonitrile / 0.17 h / 0 - 20 °C
3.2: 2 h / 0 °C
With
trimethylsilyl bromide; carbon tetrabromide; triethylamine;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C
1.2: 12.5 - 16.5 h
2.1: sodium tetrahydroborate / methanol / 0.5 h / 0 - 20 °C
2.2: 0 °C
3.1: thionyl chloride / benzene / 0.17 h / 0 °C
4.1: sodium hydroxide / methanol / 0.17 h
4.2: 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
6.1: dihydrogen peroxide; acetic acid / water / 20 °C
7.1: piperidine; benzoic acid / toluene / 2 - 3 h / Heating / reflux
8.1: carbon tetrabromide; triethylamine / acetonitrile / 0.17 h / 0 °C
8.2: 2 h / 0 °C
9.1: trimethylsilyl bromide / dichloromethane / 0.75 h / 0 °C
10.1: carbon tetrabromide; triethylamine / acetonitrile / 0.17 h / 0 - 20 °C
10.2: 2 h / 0 °C
With
piperidine; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; trimethylsilyl bromide; carbon tetrabromide; tetrabutyl ammonium fluoride; dihydrogen peroxide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; benzoic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
