(E,2Z)-4-Ethyl-2-hydroxyimino-5-nitro-hex-3-enamide

Base Information

Chemical Name:(E,2Z)-4-Ethyl-2-hydroxyimino-5-nitro-hex-3-enamide
CAS No.:138472-01-2
Molecular Formula:C₈H₁₃N₃O₄
Molecular Weight:215.209
Hs Code.:
European Community (EC) Number:685-864-2
ChEMBL ID:CHEMBL125865
Mol file:138472-01-2.mol

Synonyms:4-ethyl-2-(hydroxyimino)-5-nitro-3-hexenamide;4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide;4-ethyl-2-hydroxyimino-5-nitro-3-hexenecarboxamide;ethyl-2-(hydroxyamino)-5-nitro-3-hexenamide;FK 409;FK-409;NOR-3 cpd;NOR3 hexenamide cpd

Suppliers and Price of (E,2Z)-4-Ethyl-2-hydroxyimino-5-nitro-hex-3-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(E,E)-4-Ethyl-2-(hydroxyimino)-5-nitro-3-hexenamide
10mg
$ 265.00

Sigma-Aldrich
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide ≥98%
10mg
$ 274.00

Cayman Chemical
FK-409 ≥98%
10mg
$ 120.00

Cayman Chemical
FK-409 ≥98%
5mg
$ 68.00

Cayman Chemical
FK-409 ≥98%
1mg
$ 15.00

Cayman Chemical
FK-409 ≥98%
50mg
$ 525.00

American Custom Chemicals Corporation
4-ETHYL-2E-(HYDROXYIMINO)-5-NITRO-3E-HEXENAMIDE 95.00%
5MG
$ 505.36

American Custom Chemicals Corporation
4-ETHYL-2E-(HYDROXYIMINO)-5-NITRO-3E-HEXENAMIDE 95.00%
1MG
$ 123.90

Total 11 raw suppliers

Chemical Property of (E,2Z)-4-Ethyl-2-hydroxyimino-5-nitro-hex-3-enamide

Chemical Property:

Boiling Point:428.2 °C at 760 mmHg
Flash Point:212.7 °C
PSA：110.50000
Density:1.33 g/cm³
LogP:1.30910
Storage Temp.:−20°C
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:215.09060590
Heavy Atom Count:15
Complexity:316

Purity/Quality:

98%min ^*data from raw suppliers

(E,E)-4-Ethyl-2-(hydroxyimino)-5-nitro-3-hexenamide ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=CC(=NO)C(=O)N)C(C)[N+](=O)[O-]
Isomeric SMILES:CC/C(=C\C(=N\O)\C(=O)N)/C(C)[N+](=O)[O-]
Uses FK-409 is a NO donor. It liberates NO in a time-dependent manner with a half-life of approximately 40 minutes in phosphate buffer (pH 7.4) at 37°C. The IC50 for the inhibition of platelet aggregation is 4.9 μM. NOR-3 is a cell-permeable NO donor.

Technology Process of (E,2Z)-4-Ethyl-2-hydroxyimino-5-nitro-hex-3-enamide

There total 3 articles about (E,2Z)-4-Ethyl-2-hydroxyimino-5-nitro-hex-3-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 138472-01-2,139675-83-5,139675-84-6,163180-49-2
(E)-4-ethyl-2-[E-hydroxyimino]-5-nitro-3-hexenamide

Guidance literature:

Reference yield: 66.6%

: 92454-24-5
(E,E)-4-ethyl-2,4-hexadienamide

: 138472-01-2,139675-83-5,139675-84-6,163180-49-2
(E)-4-ethyl-2-[E-hydroxyimino]-5-nitro-3-hexenamide

Guidance literature:: With hydrogenchloride; sodium nitrite; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 63883-69-2
(E)-2-ethyl-2-butenal

: 138472-01-2,139675-83-5,139675-84-6,163180-49-2
(E)-4-ethyl-2-[E-hydroxyimino]-5-nitro-3-hexenamide

Guidance literature:: Multi-step reaction with 2 steps

1: t-BuOK

2: HCl, NaNO₂ / H₂O

With hydrogenchloride; potassium tert-butylate; sodium nitrite; In water;
DOI:10.1016/0960-894X(95)00547-7