N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Base Information

Chemical Name:N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide
CAS No.:1067648-28-5
Molecular Formula:C₄₇H₆₁N₅O₈S
Molecular Weight:856.096
Hs Code.:

N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Synonyms:N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

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Chemical Property of N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

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Technology Process of N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

There total 15 articles about N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1067648-90-1
(2S,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

: 695215-92-0
3-[methyl(methylsulfonyl)amino]-5-((1R)-1-phenylethylaminocarbonyl)benzoate acid

: 1067648-28-5
N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Guidance literature:: 3-[methyl(methylsulfonyl)amino]-5-((1R)-1-phenylethylaminocarbonyl)benzoate acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

(2S,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-butyl)-amide; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

Reference yield:

: 1056674-45-3
(3S,5S)-5-((R)-1,2-dihydroxyethyl)-3-isopropyldihydrofuran-2(3H)-one

: 1067648-28-5
N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: di(n-butyl)tin oxide / toluene / 4 h / Heating / reflux

1.2: 22 h / 90 °C

2.1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 - 1 h / 0 - 20 °C

2.2: 1 h / 60 - 70 °C

3.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / 72 h / 70 °C

4.1: hydrogen / 5 % Pd/CaCO3 / methanol; ethyl acetate

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

5.2: 0.33 h / 0 °C

With pyridine; 2-hydroxypyridin; trifluoromethylsulfonic anhydride; hydrogen; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; HATU; 5 % Pd/CaCO3; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1056674-54-4
(3S,5S)-5-[(1R)-2-(benzyloxy)-1-hydroxyethyl]-3-isopropyldihydrofuran-2(3H)-one

: 1067648-28-5
N-[(1S,2S,4S)-4-((S)-1-benzylcarbamoyl-2-methyl-butylcarbamoyl)-1-benzyloxymethyl-2-hydroxy-5-methyl-hexyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 - 1 h / 0 - 20 °C

1.2: 1 h / 60 - 70 °C

2.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / 72 h / 70 °C

3.1: hydrogen / 5 % Pd/CaCO3 / methanol; ethyl acetate

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

4.2: 0.33 h / 0 °C

With pyridine; 2-hydroxypyridin; trifluoromethylsulfonic anhydride; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; 5 % Pd/CaCO3; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;