695215-92-0

Basic information

• Product Name: Benzoic acid, 3-[methyl(methylsulfonyl)amino]-5-[[[(1R)-1-phenylethyl]amino]carbonyl]-
• CAS NO: 695215-92-0
• Molecular Formula: C18H20N2O5S
• Molecular Weight: 376.433
• Mol File: 695215-92-0.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-[methyl(methylsulfonyl)amino]-5-[[[(1R)-1-phenylethyl]amino]carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-[methyl(methylsulfonyl)amino]-5-[[[(1R)-1-phenylethyl]amino]carbonyl]-(695215-92-0)
• EPA Substance Registry System: Benzoic acid, 3-[methyl(methylsulfonyl)amino]-5-[[[(1R)-1-phenylethyl]amino]carbonyl]-(695215-92-0)

Safety Data

• Hazardous Substances Data: 695215-92-0(Hazardous Substances Data)

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 695215-94-2 3-(methoxycarbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid 
• 62814-45-3 5-methanesulphonylamino-isophthalic acid dimethyl ester 
• 695215-93-1 dimethyl-5-[methyl(methylsulfonyl)amino]isophthalate 
• 99-27-4 dimethyl 5-aminoisophthalate 
• 695215-95-3 methyl-3-[methyl(methylsulfonyl)amino]-5-((1R)-1-phenylethylaminocarbonyl)benzoate 

Downstream Products

• 1092973-27-7 5-((S)-2-{(3S,4S)-5-(3,5-difluoro-phenoxy)-3-hydroxy-4-[3-((methanesulfonyl)(methyl)amino)-5-((R)-(1-phenylethyl)carbamoyl)-benzoylamino]-pentanoylamino}-3-methylbutyrylamino)isophthalic acid dimethyl ester 
• 1092973-34-6 N-[(1S,2S)-3-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-propyl]-5-((methanesulfonyl)(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalic acid diamide 
• 1415034-16-0 C₃₃H₄₁N₃O₇S 
• 1399316-10-9 C₃₅H₄₇N₅O₅S 
• 1399316-48-3 C₃₆H₄₉N₅O₆S 
• 1067648-21-8 N-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difiuorophenoxymethyl)-2-hydroxy-pentyl]-5-(methanesulphonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide 

Relevant articles and documents

Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases

Inspired by marine cyanobacterial natural products, we synthesized modified peptides with a central statine-core unit, characteristic for aspartic protease inhibition. A series of tasiamide B analogues inhibited BACE1, a therapeutic target in Alzheimer's

COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.

COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and in the claims. The invention also relates to the use thereof for treat

β SECRETASE INHIBITOR

Disclosed is a compound represented by the formula (1) below which is useful as a drug for treating Alzheimer's disease, or a pharmaceutically acceptable salt thereof. (1) [In the formula, R1 represents a group represented by the following formula (2): (2) (wherein X represents a nitrogen atom or a group expressed as C(R5); Y represents a nitrogen atom or a group expressed as C(R6); and R5 and R6 independently represent a hydrogen atom or the like) or the like; m represents an integer of 1-6; L1 represents a single bond or the like; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group or the like; R3 represents a hydrogen atom or the like; L2 represents a single bond or the like; and R4 represents a hydrogen atom, a substituted or unsubstituted aryl group or the like.]

Design, synthesis, and X-ray structure of potent memapsin 2 (β-secretase) inhibitors with isophthalamide derivatives as the P 2 P3-ligands

Structure-based design and synthesis of a number of potent and selective memapsin 2 inhibitors are described. These inhibitors were designed based upon the X-ray structure of memapsin 2-bound inhibitor 3 that incorporates methylsulfonyl alanine as the Ps

Substituted 1,2-ethylenediamines, Methods for Preparing Them and Uses Thereof

The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1-X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.

BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed t

Structure-based design of potent and selective cell-permeable inhibitors of human β-secretase (BACE-1)

We describe the development of cell-permeable β-secretase inhibitors that demonstratively inhibit the production of the secreted amino terminal fragment of an artificial amyloid precursor protein in cell culture. In addition to potent inhibition in a cell

PHENYLCARBOXAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is a