5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde

Base Information

Chemical Name:5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde
CAS No.:1310689-20-3
Molecular Formula:C₂₂H₂₄N₄O₄
Molecular Weight:408.457
Hs Code.:

Synonyms:5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde

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Chemical Property of 5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde

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Technology Process of 5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde

There total 6 articles about 5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1310689-19-0
2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole

: 1310689-20-3
5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde

Guidance literature:: With iron(III) chloride hexahydrate; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 4-[3-(1,3-dithian-2-yl)-4-nitrobenzyl]piperidine hydrochloride

: 1310689-20-3
5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / acetonitrile / 15 h / Reflux

2: iron(III) chloride hexahydrate / dichloromethane / 3 h / 20 °C

With iron(III) chloride hexahydrate; sodium carbonate; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 1310689-15-6
2-(5-bromo-2-nitro-phenyl)-[1,3]-dithiane

: 1310689-20-3
5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / Reflux

1.2: 3 h / 65 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: sodium carbonate / acetonitrile / 15 h / Reflux

4.1: iron(III) chloride hexahydrate / dichloromethane / 3 h / 20 °C

With iron(III) chloride hexahydrate; sodium carbonate; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile; 1.2: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.03.013