2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole

Base Information

Chemical Name:2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole
CAS No.:1310689-19-0
Molecular Formula:C₂₅H₃₀N₄O₃S₂
Molecular Weight:498.67
Hs Code.:

Synonyms:2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole

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Chemical Property of 2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole

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Technology Process of 2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole

There total 5 articles about 2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 4-[3-(1,3-dithian-2-yl)-4-nitrobenzyl]piperidine hydrochloride

: 14625-40-2
2-(chloromethyl)-5-methoxy-1H-benzimidazole

: 1310689-19-0
2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole

Guidance literature:: With sodium carbonate; In acetonitrile; for 15h; Reflux;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 1310689-15-6
2-(5-bromo-2-nitro-phenyl)-[1,3]-dithiane

: 1310689-19-0
2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / Reflux

1.2: 3 h / 65 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: sodium carbonate / acetonitrile / 15 h / Reflux

With sodium carbonate; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile; 1.2: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 1310689-16-7
tert-butyl 1-[4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-yl]carboxylate

: 1310689-19-0
2-(4-(3-[1,3-dithian-2-yl]-4-nitrobenzyl)piperidin-1-ylmethyl)-5-methoxybenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: sodium carbonate / acetonitrile / 15 h / Reflux

With sodium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2011.03.013