(S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester
CAS No.:206191-43-7
Molecular Formula:C₁₃H₂₃NO₆
Molecular Weight:289.329
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 99314-44-0
(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate

: 206191-43-7
(S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester

Guidance literature:: With caesium carbonate; sodium iodide; Yield given. Multistep reaction; 1.) H₂O, 2.) DMF, room temperature, 48 h;
DOI:10.1021/jo972294l

Reference yield:

: 206191-43-7
(S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester

: 206191-49-3
1-(N-tert-butyloxycarbonyl-(1S,2S)-1-amino-2-hydroxypropyl)-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BF₃*Et₂O, 2.) TEA / 1.) CH₂Cl₂, 0 deg C to room temperature, 6 h, 2.) 30 min

2: 1.) DMSO, (COCl)2, 2.) DIPEA / 1.) CH₂Cl₂, -78 deg C, 1.5 h, 2.) -78 deg C, 30 min; 0 deg C, 10 min

3: diethyl ether; toluene / 0.08 h / -78 °C

With oxalyl dichloride; TEA; boron trifluoride diethyl etherate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In diethyl ether; toluene;
DOI:10.1021/jo972294l

Reference yield:

: 206191-43-7
(S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester

: 206191-45-9
1-[N-(tert-butyloxycarbonyl)-(1S)-1-amino-2-hydroxyethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane

Guidance literature:: With TEA; boron trifluoride diethyl etherate; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C to room temperature, 6 h, 2.) 30 min;
DOI:10.1021/jo972294l