1-[N-TERT-BUTOXYCARBONYL-(1S)-1-AMINO-2-HYDROXYETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE

Base Information

Chemical Name:1-[N-TERT-BUTOXYCARBONYL-(1S)-1-AMINO-2-HYDROXYETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE
CAS No.:206191-45-9
Molecular Formula:C13H23 N O6
Molecular Weight:289.329
Hs Code.:
Mol file:206191-45-9.mol

Synonyms:Carbamicacid, [2-hydroxy-1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)ethyl]-,1,1-dimethylethyl ester, (S)-

Suppliers and Price of 1-[N-TERT-BUTOXYCARBONYL-(1S)-1-AMINO-2-HYDROXYETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-[N-TERT-BUTOXYCARBONYL-(1S)-1-AMINO-2-HYDROXYETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO-[2.2.2]-OCTANE 95.00%
5MG
$ 501.27

Total 1 raw suppliers

Chemical Property of 1-[N-TERT-BUTOXYCARBONYL-(1S)-1-AMINO-2-HYDROXYETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE

Chemical Property:

PSA：86.25000
LogP:1.00000

Purity/Quality:

99% ^*data from raw suppliers

1-[N-TERT-BUTOXYCARBONYL-(1S)-1-AMINO-2-HYDROXYETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO-[2.2.2]-OCTANE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-[N-TERT-BUTOXYCARBONYL-(1S)-1-AMINO-2-HYDROXYETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE

There total 3 articles about 1-[N-TERT-BUTOXYCARBONYL-(1S)-1-AMINO-2-HYDROXYETHYL]-4-METHYL-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99314-44-0
(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate

: 206191-45-9
1-[N-(tert-butyloxycarbonyl)-(1S)-1-amino-2-hydroxyethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Cs₂CO₃, 2.) NaI / 1.) H₂O, 2.) DMF, room temperature, 48 h

2: 1.) BF₃*Et₂O, 2.) TEA / 1.) CH₂Cl₂, 0 deg C to room temperature, 6 h, 2.) 30 min

With TEA; boron trifluoride diethyl etherate; caesium carbonate; sodium iodide;
DOI:10.1021/jo972294l

Reference yield:

: 3143-02-0
3-hydroxymethyl-3-methyloxethane

: 206191-45-9
1-[N-(tert-butyloxycarbonyl)-(1S)-1-amino-2-hydroxyethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / pyridine / 1.5 h

2: 1.) Cs₂CO₃, 2.) NaI / 1.) H₂O, 2.) DMF, room temperature, 48 h

3: 1.) BF₃*Et₂O, 2.) TEA / 1.) CH₂Cl₂, 0 deg C to room temperature, 6 h, 2.) 30 min

With TEA; boron trifluoride diethyl etherate; caesium carbonate; sodium iodide; In pyridine;
DOI:10.1021/jo972294l

Reference yield:

: 206191-43-7
(S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid 3-methyl-oxetan-3-ylmethyl ester

: 206191-45-9
1-[N-(tert-butyloxycarbonyl)-(1S)-1-amino-2-hydroxyethyl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane

Guidance literature:: With TEA; boron trifluoride diethyl etherate; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C to room temperature, 6 h, 2.) 30 min;
DOI:10.1021/jo972294l