methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate

Base Information

Chemical Name:methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate
CAS No.:1370228-97-9
Molecular Formula:C₂₂H₂₈N₂O₇S
Molecular Weight:464.54
Hs Code.:

Synonyms:methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate

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Chemical Property of methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate

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Technology Process of methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate

There total 2 articles about methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1370228-77-5
methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)amino)acetate

: 74-88-4
methyl iodide

: 1370228-97-9
methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate

Guidance literature:: methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)amino)acetate; With sodium hydride; In acetonitrile; for 0.5h; Cooling;

methyl iodide; In acetonitrile; Cooling; Reflux;
DOI:10.1016/j.bmc.2012.01.030

Reference yield:

: 174466-48-9
methyl -glycinate

: 1370228-97-9
methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C

2.1: sodium hydride / acetonitrile / 0.5 h / Cooling

2.2: Cooling; Reflux

With di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; acetonitrile; 1.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.01.030

Reference yield: 64.0%

: 1370228-97-9
methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate

: 1370228-99-1
2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetic acid

Guidance literature:: methyl 2-((N-(tert-butoxycarbonyl)-N-(3-phenoxybenzyl)sulfamoyl)(methyl)amino)acetate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

With hydrogenchloride; In water; pH=Ca. 2;
DOI:10.1016/j.bmc.2012.01.030