methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate

Base Information

• Chemical Name: methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate
• CAS No.: 914646-67-6
• Molecular Formula: C₁₃H₁₅BrO₄
• Molecular Weight: 315.164
• Mol file: 914646-67-6.mol

Synonyms:methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate

Chemical Property of methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate

There total 1 articles about methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

methyl 5-amino-2-methylbenzoate (18595-12-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate (914646-67-6)

Guidance literature:

methyl 5-amino-2-methylbenzoate; With hydrogen bromide; sodium nitrite; In methanol; acetone; cooling;

acrylic acid methyl ester; With copper(I) oxide; In methanol; acetone; at 35 - 40 ℃;

DOI:10.1016/j.bmc.2006.07.008

Reference yield: 100.0%

methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate (914646-67-6) → (E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-methylbenzoate (914646-69-8)

Guidance literature:

With 1,5-Diazabicyclo[5.4.0]undec-5-ene; In toluene; Heating;

DOI:10.1016/j.bmc.2006.07.008

Reference yield:

methyl 5-(2-(methoxycarbonyl)-2-bromoethyl)-2-methylbenzoate (914646-67-6) → (E)-methyl 3-(2-(3-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylate (914646-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 1,5-diazabicyclo[5.4.0]undec-5-ene / toluene / Heating

2: 49 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / Heating

3: 71 percent / triethylamine / methanol / Heating

With N-Bromosuccinimide; triethylamine; 1,5-Diazabicyclo[5.4.0]undec-5-ene; dibenzoyl peroxide; In methanol; tetrachloromethane; toluene;

DOI:10.1016/j.bmc.2006.07.008

upstream raw materials:

methyl 5-amino-2-methylbenzoate

acrylic acid methyl ester

Downstream raw materials:

(E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-methylbenzoate

(E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-bromomethylbenzoate

(E)-methyl 3-(1-oxo-2-phenethylisoindolin-6-yl)acrylate

(E)-methyl 3-(2-(3-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylate