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914646-78-9

2-Propenoic acid, 3-[2-[(3-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1H-isoindol-5-yl]-, methyl ester, (2E)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 2-Propenoic acid, 3-[2-[(3-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1H-isoindol-5-yl]-, methyl ester, (2E)-

    Cas No: 914646-78-9

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  • 914646-78-9 Structure

  • Basic information

    1. Product Name: 2-Propenoic acid, 3-[2-[(3-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1H-isoindol-5-yl]-, methyl ester, (2E)-
    2. Synonyms:
    3. CAS NO:914646-78-9
    4. Molecular Formula: C19H16ClNO3
    5. Molecular Weight: 341.794
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 914646-78-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Propenoic acid, 3-[2-[(3-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1H-isoindol-5-yl]-, methyl ester, (2E)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Propenoic acid, 3-[2-[(3-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1H-isoindol-5-yl]-, methyl ester, (2E)-(914646-78-9)
    11. EPA Substance Registry System: 2-Propenoic acid, 3-[2-[(3-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1H-isoindol-5-yl]-, methyl ester, (2E)-(914646-78-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 914646-78-9(Hazardous Substances Data)

914646-78-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 914646-78-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,6,4 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 914646-78:
(8*9)+(7*1)+(6*4)+(5*6)+(4*4)+(3*6)+(2*7)+(1*8)=189
189 % 10 = 9
So 914646-78-9 is a valid CAS Registry Number.

914646-78-9Relevant articles and documents

Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors

Shinji, Chihiro,Maeda, Satoko,Imai, Keisuke,Yoshida, Minoru,Hashimoto, Yuichi,Miyachi, Hiroyuki

, p. 7625 - 7651 (2007/10/03)

A series of hydroxamic acid derivatives bearing a cyclic amide/imide group as a linker and/or cap structure, prepared during our structural development studies based on thalidomide, showed class-selective potent histone deacetylase (HDAC)-inhibitory activity. Structure-activity relationship studies indicated that the steric character of the substituent introduced at the cyclic amide/imide nitrogen atom, the presence of the amide/imide carbonyl group, the hydroxamic acid structure, the shape of the linking group, and the distance between the zinc-binding hydroxamic acid group and the cap structure are all important for HDAC-inhibitory activity and class selectivity. A representative compound (30w) showed potent p21 promoter activity, comparable with that of trichostatin A (TSA), and its cytostatic activity against cells of the human prostate cell line LNCaP was more potent than that of the well-known HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA).

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