N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester

Base Information

• Chemical Name: N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester
• CAS No.: 1590449-58-3
• Molecular Formula: C₂₂H₂₄BrNO₅
• Molecular Weight: 462.34
• Mol file: 1590449-58-3.mol

Synonyms:N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester

Chemical Property of N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester

There total 3 articles about N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-bromophenylacetic acid (4870-65-9,31302-84-8) + N-benzoyl-L-threonine isopropyl ester (157943-64-1) → N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester (1590449-58-3)

Guidance literature:

2-bromophenylacetic acid; N-benzoyl-L-threonine isopropyl ester; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Inert atmosphere;

In hexane; ethyl acetate; at 20 ℃; for 168h; Inert atmosphere; Resolution of racemate;

In hexane; ethyl acetate; at 20 ℃; Solvent; Reagent/catalyst; Inert atmosphere; Resolution of racemate;

DOI:10.1002/ejoc.201301539

Reference yield:

2-bromophenylacetic acid (4870-65-9,31302-84-8) + N-benzoyl-L-threonine isopropyl ester (157943-64-1) → N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester (1590449-58-3) + N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester (1590449-61-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Overall yield = 70 %; Inert atmosphere;

DOI:10.1002/ejoc.201301539

Reference yield:

N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester (1581728-95-1) → N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester (1590449-58-3)

Guidance literature:

at 20 ℃; for 720h; Inert atmosphere; Sealed tube; Resolution of racemate;

DOI:10.1002/ejoc.201301539

upstream raw materials:

2-bromophenylacetic acid

N-benzoyl-L-threonine isopropyl ester

N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester

Downstream raw materials:

N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester

N-benzoyl-O-[α-(p-methylphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester

N-benzoyl-O-[α-(p-chlorophenylthio)-α-phenylacetyl]-L-threonine isopropyl ester

N-benzoyl-O-[α-(p-methoxycarbonylphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester