N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester

Base Information

• Chemical Name: N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester
• CAS No.: 1590449-67-4
• Molecular Formula: C₂₉H₃₁NO₆S
• Molecular Weight: 521.634
• Mol file: 1590449-67-4.mol

Synonyms:N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester

Chemical Property of N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester

There total 4 articles about N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-Methoxybenzenethiol (696-63-9) + N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester (1590449-58-3) → N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester (1590449-67-4)

Guidance literature:

With potassium carbonate; In toluene; at 20 ℃; for 4h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201301539

Reference yield:

N-benzoyl-L-threonine isopropyl ester (157943-64-1) → N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester (1590449-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

2: potassium carbonate / toluene / 4 h / 20 °C / Inert atmosphere

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1002/ejoc.201301539

Reference yield:

2-bromophenylacetic acid (4870-65-9,31302-84-8) → N-benzoyl-O-[α-(p-methoxyphenylthio)-α-phenylacetyl]-L-threonine isopropyl ester (1590449-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

2: potassium carbonate / toluene / 4 h / 20 °C / Inert atmosphere

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1002/ejoc.201301539

upstream raw materials:

N-benzoyl-L-threonine isopropyl ester

4-Methoxybenzenethiol

N-benzoyl-O-(α-bromo-α-phenylacetyl)-L-threonine isopropyl ester

2-bromophenylacetic acid