methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate

Base Information

• Chemical Name: methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate
• CAS No.: 1374748-58-9
• Molecular Formula: C₁₇H₁₂Br₂N₂O₄
• Molecular Weight: 468.101
• Mol file: 1374748-58-9.mol

Synonyms:methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate

Chemical Property of methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate

There total 2 articles about methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-bromo-phenol (106-41-2) + 7-bromo-3-chloroquinoxalin-2(1H)-one (1374748-38-5) + bromoacetic acid methyl ester (96-32-2) → methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate (1374748-58-9)

Guidance literature:

4-bromo-phenol; 7-bromo-3-chloroquinoxalin-2(1H)-one; With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 12h;

bromoacetic acid methyl ester; With potassium carbonate; In acetonitrile; at 55 ℃; for 0.5h;

DOI:10.1002/cmdc.201200054

Reference yield:

7-bromo-2,3-dichloroquinoxaline (108229-82-9) → methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate (1374748-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 12 h / 65 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 75 °C

2.2: 0.5 h / 55 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201200054

Reference yield: 83.0%

methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate (1374748-58-9) → 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid (1374748-84-1)

Guidance literature:

methyl 2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1002/cmdc.201200054

upstream raw materials:

4-bromo-phenol

7-bromo-3-chloroquinoxalin-2(1H)-one

bromoacetic acid methyl ester

7-bromo-2,3-dichloroquinoxaline

Downstream raw materials:

2-(7-bromo-3-(4-bromophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid