108229-82-9

Basic information

• Product Name: 6-bromo-2,3-dichloroquinoxaline
• Synonyms: 6-bromo-2,3-dichloroquinoxaline;7-bromo-2,3-dichloroquinoxaline
• CAS NO: 108229-82-9
• Molecular Formula: C₈H₃BrCl₂N₂
• Molecular Weight: 277.9328
• Mol File: 108229-82-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 326.707 °C at 760 mmHg
• Flash Point: 151.387 °C
• Appearance: /
• Density: 1.852 g/cm³
• Refractive Index: 1.696
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -6.33±0.48(Predicted)
• CAS DataBase Reference: 6-bromo-2,3-dichloroquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-2,3-dichloroquinoxaline(108229-82-9)
• EPA Substance Registry System: 6-bromo-2,3-dichloroquinoxaline(108229-82-9)

Safety Data

• Hazardous Substances Data: 108229-82-9(Hazardous Substances Data)

Usage

General Description

6-Bromo-2,3-dichloroquinoxaline is a chemical compound with the molecular formula C8H3BrCl2N2. It is a halogenated quinoxaline derivative that is commonly used in organic synthesis and medicinal chemistry research. 6-Bromo-2,3-dichloroquinoxaline is known for its potential applications in the development of pharmaceutical drugs, as it exhibits a wide range of biological activities, including antimicrobial and anticancer properties. 6-Bromo-2,3-dichloroquinoxaline's unique structure and reactivity make it a valuable building block for the synthesis of various heterocyclic compounds and drug candidates. Its versatility and potential pharmaceutical applications make it an important compound in the field of organic chemistry.

InChI:InChI=1/C8H3BrCl2N2/c9-4-1-2-5-6(3-4)13-8(11)7(10)12-5/h1-3H

Upstream product

• 1575-37-7 4-Bromo-benzene-1,2-diamine 
• 1910-90-3 6-bromo-1,4-dihydro-quinoxaline-2,3-dione 
• 95-92-1 oxalic acid diethyl ester 

Relevant articles and documents

A One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives 3a–n. The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamine and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines have been obtained in good to excellent overall yields. Eight known compounds 3a–3h were characterized by IR, 1H-NMR, and mass spectroscopies. Compounds 3i–3n without spectroscopic data were characterized by IR, 1H-NMR, 13C-NMR, and mass spectroscopies.

Novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and preparation and application thereof

The invention provides a novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and a preparation method and application thereof, and belongs to the field of chemical medicines. The derivative is a compound as shown in a formula I, or a salt thereof, or a stereoisomer thereof. The compound is low in toxicity or basically non-toxic to normal cells, has an obvious inhibition effect to tumor cell lines, particularly has good lipid toxicity selectivity to tumor cells such as liver cancer, lung cancer and the like in vivo, and has an obvious inhibition effect; meanwhile, the compound can effectively activate SREBP1 and PPAR gamma, inhibit lipid transport MTTP, cause lipid aggregation in tumor cells and cause lipid toxicity of the tumor cells. The compound can be used for treating liver cancer, lung cancer and the like in a molecular targeting manner, is low in toxicity or even non-toxic, and has a good application prospect.