(R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

Base Information

• Chemical Name: (R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide
• CAS No.: 1194737-19-3
• Molecular Formula: Br*C₂₇H₃₄FN₄O₃
• Molecular Weight: 561.494
• Mol file: 1194737-19-3.mol

Synonyms:(R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

Chemical Property of (R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

There total 5 articles about (R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-N-pyrazin-2-yl-acetamide (787628-96-0) + 1-(3-fluoro-phenyl)-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (1194737-27-3) → (R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide (1194737-19-3)

Guidance literature:

In acetonitrile; for 72h;

Reference yield:

1-(3-fluoro-phenyl)-cyclohept-4-ene carboxylic acid methyl ester (1194737-23-9) → (R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide (1194737-19-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium on carbon / methanol / 3040.2 Torr

2.1: toluene

2.2: 8 h / Reflux

3.1: acetonitrile / 72 h

With hydrogen; palladium on carbon; In methanol; toluene; acetonitrile;

Reference yield:

methyl (3-fluorophenyl)acetate (64123-77-9) → (R)-3-[1-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide (1194737-19-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 h / Reflux; Inert atmosphere

3.1: hydrogen / palladium on carbon / methanol / 3040.2 Torr

4.1: toluene

4.2: 8 h / Reflux

5.1: acetonitrile / 72 h

With hydrogen; lithium hexamethyldisilazane; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on carbon; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

upstream raw materials:

2-bromo-N-pyrazin-2-yl-acetamide

1-(3-fluoro-phenyl)-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

1-(3-fluoro-phenyl)-cyclohept-4-ene carboxylic acid methyl ester

1-(3-Fluoro-phenyl)-cycloheptanecarboxylic acid methyl ester