(3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline

Base Information

Chemical Name:(3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline
CAS No.:865087-01-0
Molecular Formula:C₁₆H₂₃NO₂S₂
Molecular Weight:325.496
Hs Code.:

Synonyms:(3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline

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Technology Process of (3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline

There total 3 articles about (3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 865086-94-8
(Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide

: 107-02-8,25068-14-8
acrolein

: 865087-01-0
(3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline

Guidance literature:: (Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide; acrolein; With bis[(S)-BINOL/Ti(IV)]; In dichloromethane; at -40 ℃; for 24h;

With sodium tetrahydroborate; In ethanol; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ja0523284

Reference yield:

: 4882-97-7
2-methyl-1,3-dithian-2-carboxaldehyde

: 865087-01-0
(3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzene / 12 h

2.1: bis[(S)-BINOL/Ti(IV)] complex / CH₂Cl₂ / 24 h / -40 °C

2.2: 86 percent / NaBH₄ / CH₂Cl₂; ethanol / 0.5 h / 0 °C

With bis[(S)-BINOL/Ti(IV)]; In dichloromethane; benzene;
DOI:10.1021/ja0523284

Reference yield:

: 622-30-0
N-benzyl hydroxylalmine

: 865087-01-0
(3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzene / 12 h

2.1: bis[(S)-BINOL/Ti(IV)] complex / CH₂Cl₂ / 24 h / -40 °C

2.2: 86 percent / NaBH₄ / CH₂Cl₂; ethanol / 0.5 h / 0 °C

With bis[(S)-BINOL/Ti(IV)]; In dichloromethane; benzene;
DOI:10.1021/ja0523284