(Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide

Base Information

• Chemical Name: (Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide
• CAS No.: 865086-94-8
• Molecular Formula: C₁₃H₁₇NOS₂
• Molecular Weight: 267.416
• Mol file: 865086-94-8.mol

Synonyms:(Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide

Chemical Property of (Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide

There total 1 articles about (Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1,3-dithian-2-carboxaldehyde (4882-97-7) + N-benzyl hydroxylalmine (622-30-0) → (Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide (865086-94-8)

Guidance literature:

In benzene; for 12h;

DOI:10.1021/ja0523284

Reference yield: 86.0%

(Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide (865086-94-8) + acrolein (107-02-8,25068-14-8) → (3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline (865087-01-0)

Guidance literature:

(Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide; acrolein; With bis[(S)-BINOL/Ti(IV)]; In dichloromethane; at -40 ℃; for 24h;

With sodium tetrahydroborate; In ethanol; dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/ja0523284

Reference yield:

(Z)-N-(2-methyl-1,3-dithian-2-yl)methylidenebenzylamine N-oxide (865086-94-8) → (3S,4S)-3-acetyl-2-benzyl-4-hydroxymethylisoxazoline

Guidance literature:

Multi-step reaction with 2 steps

1.1: bis[(S)-BINOL/Ti(IV)] complex / CH₂Cl₂ / 24 h / -40 °C

1.2: 86 percent / NaBH₄ / CH₂Cl₂; ethanol / 0.5 h / 0 °C

2.1: 63 percent / aq. HgO; HgCl₂ / acetonitrile / 1 h / 20 °C

With bis[(S)-BINOL/Ti(IV)]; mercury dichloride; mercury(II) oxide; In dichloromethane; acetonitrile;

DOI:10.1021/ja0523284

upstream raw materials:

2-methyl-1,3-dithian-2-carboxaldehyde

N-benzyl hydroxylalmine

Downstream raw materials:

(3S,4S)-2-benzyl-4-hydroxymethyl-3-(2-methyl-1,3-dithian-2-yl)isoxazoline