1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone

Base Information

Chemical Name:1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone
CAS No.:527368-79-2
Molecular Formula:C₂₁H₁₇Cl₂N₃O₂
Molecular Weight:414.291
Hs Code.:

Synonyms:1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone

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Technology Process of 1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone

There total 1 articles about 1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 527384-59-4
2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carbonyl chloride

: 4-oxopiperidin-1-ium 2,2,2-trifluoroacetate

: 527368-79-2
1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 17h;

Reference yield: 61.0%

: 110-00-9
furan

: 527368-79-2
1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone

: 1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-irnidazol-4-yl]carbonyl}-4-(2-furyl)-4-piperidinol

Guidance literature:: furan; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield: 46.0%

: 527368-79-2
1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone

: 352-13-6
4-flourophenylmagnesium bromide

: 1-[[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl]-4-(4-fluorophenyl)-4-piperidinol

Guidance literature:: 1-{[2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazol-4-yl]carbonyl}-4-piperidinone; 4-flourophenylmagnesium bromide; In tetrahydrofuran; at -78 - 30 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran;