1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane

Base Information

Chemical Name:1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane
CAS No.:294676-97-4
Molecular Formula:C₂₅H₄₀N₄O₆S
Molecular Weight:524.682
Hs Code.:

Synonyms:1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane

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Chemical Property of 1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane

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Technology Process of 1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane

There total 5 articles about 1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 116861-31-5
tert-butyl N-(3-chloropropyl)carbamate

: 294676-96-3
1-N-(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N'-tosyl-ethylenediamine

: 294676-97-4
1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 110 ℃; for 4h;
DOI:10.1016/S0040-4020(00)00382-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 294676-97-4
1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / triethylamine / CHCl₃

2: 87 percent / sodium hydride / dimethylformamide; various solvent(s) / 4 h / 110 °C

With sodium hydride; triethylamine; In chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: Condensation;
DOI:10.1016/S0040-4020(00)00382-3

Reference yield:

: 294676-95-2
1-N-cyanoethyl-4-N'-tosyl-ethylenediamine

: 294676-97-4
1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / triethylamine / CHCl₃ / 2 h / Heating

2: 87 percent / sodium hydride / dimethylformamide; various solvent(s) / 4 h / 110 °C

With sodium hydride; triethylamine; In chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: Condensation;
DOI:10.1016/S0040-4020(00)00382-3