1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane

Base Information

Chemical Name:1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane
CAS No.:294676-98-5
Molecular Formula:C₂₅H₄₄N₄O₆S
Molecular Weight:528.714
Hs Code.:

Synonyms:1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane

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Chemical Property of 1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane

Chemical Property:

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Technology Process of 1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane

There total 7 articles about 1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 294676-97-4
1,8-N,N'-bis(tert-butoxycarbonyl)-1-N-cyanoethyl-4-N''-tosyl-1,4,8-triazaoctane

: 294676-98-5
1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane

Guidance literature:: With sodium tetrahydroborate; cobalt(II) chloride; In methanol;
DOI:10.1016/S0040-4020(00)00382-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 294676-98-5
1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / triethylamine / CHCl₃

2: 87 percent / sodium hydride / dimethylformamide; various solvent(s) / 4 h / 110 °C

3: 87 percent / CoCl₂*6H₂O; NaBH₄ / methanol

With sodium tetrahydroborate; sodium hydride; triethylamine; cobalt(II) chloride; In methanol; chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: Condensation / 3: Reduction;
DOI:10.1016/S0040-4020(00)00382-3

Reference yield:

: 294676-95-2
1-N-cyanoethyl-4-N'-tosyl-ethylenediamine

: 294676-98-5
1,8-N,N'-bis(tert-butoxycarbonyl)-5-N''-tosyl-1,5,8,12-tetraazadodecane

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / triethylamine / CHCl₃ / 2 h / Heating

2: 87 percent / sodium hydride / dimethylformamide; various solvent(s) / 4 h / 110 °C

3: 87 percent / CoCl₂*6H₂O; NaBH₄ / methanol

With sodium tetrahydroborate; sodium hydride; triethylamine; cobalt(II) chloride; In methanol; chloroform; N,N-dimethyl-formamide; 1: Acylation / 2: Condensation / 3: Reduction;
DOI:10.1016/S0040-4020(00)00382-3