tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate

Base Information

• Chemical Name: tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate
• CAS No.: 1363467-49-5
• Molecular Formula: C₂₆H₃₉N₃O₂
• Molecular Weight: 425.615
• Mol file: 1363467-49-5.mol

Synonyms:tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate

Chemical Property of tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate

There total 4 articles about tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-amino-4-[(tert-butyloxycarbonyl)amino]butane (68076-36-8) + 3-(dibenzylamino)propyl methane sulfonate (1363467-46-2) → tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate (1363467-49-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 70 ℃; for 24h;

DOI:10.1016/j.tetlet.2012.01.074

Reference yield:

1-amino-4-[(tert-butyloxycarbonyl)amino]butane (68076-36-8) + 3-(dibenzylamino)propyl methane sulfonate (1363467-46-2) → tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate (1363467-49-5) + tert-butyl (4-(bis(3-(dibenzylamino)propyl)amino)butyl)carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 ℃; for 16h;

DOI:10.1016/j.ejmech.2018.02.087

Reference yield:

3-(N,N-dibenzylamino)-1-propanol (3161-51-1) → tert-butyl (4-((3-(dibenzylamino)propyl)amino)butyl)carbamate (1363467-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 24 h / 70 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2012.01.074

upstream raw materials:

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

3-(dibenzylamino)propyl methane sulfonate

3-(N,N-dibenzylamino)-1-propanol

benzyl bromide

Downstream raw materials:

N₁-[3,4-bis(benzyloxy)-benzoyl]-N₈-tert-butyloxycarbonyl-spermidine